TOLB_VIBCH
ID TOLB_VIBCH Reviewed; 450 AA.
AC Q9KR11;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=VC_1836;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; AE003852; AAF94984.1; -; Genomic_DNA.
DR PIR; H82151; H82151.
DR RefSeq; NP_231470.1; NC_002505.1.
DR RefSeq; WP_000476637.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KR11; -.
DR SMR; Q9KR11; -.
DR STRING; 243277.VC_1836; -.
DR DNASU; 2613590; -.
DR EnsemblBacteria; AAF94984; AAF94984; VC_1836.
DR GeneID; 57740471; -.
DR KEGG; vch:VC_1836; -.
DR PATRIC; fig|243277.26.peg.1752; -.
DR eggNOG; COG0823; Bacteria.
DR HOGENOM; CLU_047123_0_0_6; -.
DR OMA; VREPSWG; -.
DR BioCyc; VCHO:VC1836-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR InterPro; IPR007195; TolB_N.
DR Pfam; PF07676; PD40; 3.
DR Pfam; PF04052; TolB_N; 1.
DR TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 23..450
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_0000034689"
SQ SEQUENCE 450 AA; 49645 MW; 360F2A88E9663505 CRC64;
MFKRLVFVLM LIGTGFSNIA NAALELVITD GIDSARPIAI VPFKWEGATK LPEDVSAVIA
SDLQRSGKFS PVPTSKMPQT PYSEEQVNFG KWTSMGVDSL LTGTITQNAE GSYVISYQLV
DIVRGQLTQG QSKALSQDGQ LVLSKDHVLF NKVATVPASR MREYAHRIAD LVYEELTGER
GAFLTRIAYV VVNDKDPYPY QLRIADYDGY NERLVLRSKQ PLMSPAWSPD GQTLAYVSFQ
NGQAEIYMMN IYSGKREKLT SFPRHNGAPR FSPDGKTLAL VLSKTGNLQV YTMDLATRRL
TEVTSGRSNN TEPFWHPDGK SLIFTSDRGG KPQIYQVNLS GGETKRLTWQ GSQNLGGQIT
PDGKFLVMVN RSDSGFNLAK QDLETGAMQI LTKTLLDESP SIAPNGGMVI YSSIYNKANV
LSMVSIDGRF KARLPATNGR VRAPAWSPFL