TOLB_YERPE
ID TOLB_YERPE Reviewed; 430 AA.
AC Q8ZGZ1; Q0WHS1;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671};
GN OrderedLocusNames=YPO1124, y3055, YP_1032;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. TolB occupies a key intermediary
CC position in the Tol-Pal system because it communicates directly with
CC both membrane-embedded components, Pal in the outer membrane and TolA
CC in the inner membrane. {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; AL590842; CAL19790.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM86605.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS61282.1; -; Genomic_DNA.
DR PIR; AD0138; AD0138.
DR RefSeq; WP_002210738.1; NZ_WUCM01000016.1.
DR RefSeq; YP_002346167.1; NC_003143.1.
DR PDB; 4PWZ; X-ray; 1.73 A; A/B=23-430.
DR PDB; 4R40; X-ray; 2.50 A; A/C=23-430.
DR PDBsum; 4PWZ; -.
DR PDBsum; 4R40; -.
DR AlphaFoldDB; Q8ZGZ1; -.
DR SMR; Q8ZGZ1; -.
DR IntAct; Q8ZGZ1; 1.
DR STRING; 214092.YPO1124; -.
DR PaxDb; Q8ZGZ1; -.
DR DNASU; 1148002; -.
DR EnsemblBacteria; AAM86605; AAM86605; y3055.
DR EnsemblBacteria; AAS61282; AAS61282; YP_1032.
DR GeneID; 66842411; -.
DR KEGG; ype:YPO1124; -.
DR KEGG; ypk:y3055; -.
DR KEGG; ypm:YP_1032; -.
DR PATRIC; fig|214092.21.peg.1417; -.
DR eggNOG; COG0823; Bacteria.
DR HOGENOM; CLU_047123_0_0_6; -.
DR OMA; VREPSWG; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR InterPro; IPR007195; TolB_N.
DR Pfam; PF07676; PD40; 4.
DR Pfam; PF04052; TolB_N; 1.
DR TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Periplasm; Reference proteome;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 22..430
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_0000034702"
FT STRAND 26..29
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 34..39
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:4PWZ"
FT HELIX 54..64
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 67..70
FT /evidence="ECO:0007829|PDB:4PWZ"
FT HELIX 73..75
FT /evidence="ECO:0007829|PDB:4PWZ"
FT HELIX 83..85
FT /evidence="ECO:0007829|PDB:4PWZ"
FT HELIX 88..92
FT /evidence="ECO:0007829|PDB:4PWZ"
FT TURN 93..95
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 98..106
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 112..120
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 122..125
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 127..136
FT /evidence="ECO:0007829|PDB:4PWZ"
FT HELIX 138..140
FT /evidence="ECO:0007829|PDB:4PWZ"
FT HELIX 141..157
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 166..172
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 174..177
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 180..186
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 193..200
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 202..207
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 211..218
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 222..230
FT /evidence="ECO:0007829|PDB:4PWZ"
FT TURN 231..233
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 236..242
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 247..251
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 255..262
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 269..274
FT /evidence="ECO:0007829|PDB:4PWZ"
FT TURN 275..277
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 280..282
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 290..295
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 299..306
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 313..318
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 330..339
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 343..351
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 357..362
FT /evidence="ECO:0007829|PDB:4PWZ"
FT TURN 363..365
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 368..370
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 375..382
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 386..395
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 398..405
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 411..413
FT /evidence="ECO:0007829|PDB:4PWZ"
FT STRAND 418..426
FT /evidence="ECO:0007829|PDB:4PWZ"
SQ SEQUENCE 430 AA; 46045 MW; 3A64DDE78A56529B CRC64;
MKQAFRVALG FLVLWASVLH AEVRIEITQG VDSARPIGVV PFKWMGPGTP PEEIGAIVGA
DLRNSGKFNP IDAARMPQQP STAAEVTPAA WTALGIDAVV VGQVQPSADG SYVVSYQLVD
TSGSAGSILA QNQYKVTKQW LRYSAHTVSD EVFEKLTGIK GAFRTRIAYV VKTNGGKFPH
ELRVSDYDGY NQFVVHRSPE PLMSPAWSPD GSKIAYVTFE SGKSALVIQT LANGAIRQVA
SFPRHNGAPA FSPDGTKLAF ALSKSGSLNL YVMDLASGQI SQVTDGRSNN TEPSWFPDSQ
NLAYTSDQGG RPQVYKVNIN GGVPQRITWE GSQNQNADVS PDGKFLVLVS SNGGAQHIAK
QDLETGAVQV LTDTLLDETP SIAPNGTMVI YSSTQGLGSV LQLVSTDGRF KARLPATDGQ
VKFPAWSPYL
