BTNL3_HUMAN
ID BTNL3_HUMAN Reviewed; 466 AA.
AC Q6UXE8; Q496L7; Q9Y2C7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Butyrophilin-like protein 3;
DE AltName: Full=Butyrophilin-like receptor;
DE Flags: Precursor;
GN Name=BTNL3; Synonyms=BTNLR, COLF4100; ORFNames=UNQ744/PRO1472;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Colon mucosa;
RX PubMed=10429365; DOI=10.1007/s100380050153;
RA Shibui A., Tsunoda T., Seki N., Suzuki Y., Sugano S., Sugane K.;
RT "Cloning, expression analysis, and chromosomal localization of a novel
RT butyrophilin-like receptor.";
RL J. Hum. Genet. 44:249-252(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6UXE8; Q6UX41: BTNL8; NbExp=2; IntAct=EBI-21583619, EBI-4314379;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UXE8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UXE8-2; Sequence=VSP_012716, VSP_012717;
CC -!- TISSUE SPECIFICITY: Expressed in small intestine, colon, testis,
CC spleen, and leukocyte. {ECO:0000269|PubMed:10429365}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
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DR EMBL; AB020625; BAA76664.1; -; mRNA.
DR EMBL; AY358385; AAQ88751.1; -; mRNA.
DR EMBL; AC091874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471165; EAW53730.1; -; Genomic_DNA.
DR EMBL; BC100800; AAI00801.1; -; mRNA.
DR EMBL; BC100801; AAI00802.1; -; mRNA.
DR EMBL; BC100802; AAI00803.1; -; mRNA.
DR CCDS; CCDS47358.1; -. [Q6UXE8-1]
DR RefSeq; NP_932079.1; NM_197975.2. [Q6UXE8-1]
DR AlphaFoldDB; Q6UXE8; -.
DR SMR; Q6UXE8; -.
DR BioGRID; 116122; 31.
DR IntAct; Q6UXE8; 9.
DR STRING; 9606.ENSP00000341787; -.
DR BioMuta; BTNL3; -.
DR DMDM; 296434411; -.
DR jPOST; Q6UXE8; -.
DR MassIVE; Q6UXE8; -.
DR PaxDb; Q6UXE8; -.
DR PeptideAtlas; Q6UXE8; -.
DR PRIDE; Q6UXE8; -.
DR Antibodypedia; 29692; 152 antibodies from 19 providers.
DR DNASU; 10917; -.
DR Ensembl; ENST00000342868.7; ENSP00000341787.6; ENSG00000168903.9. [Q6UXE8-1]
DR GeneID; 10917; -.
DR KEGG; hsa:10917; -.
DR MANE-Select; ENST00000342868.7; ENSP00000341787.6; NM_197975.3; NP_932079.1.
DR UCSC; uc003mmr.3; human. [Q6UXE8-1]
DR CTD; 10917; -.
DR DisGeNET; 10917; -.
DR GeneCards; BTNL3; -.
DR HGNC; HGNC:1143; BTNL3.
DR HPA; ENSG00000168903; Tissue enriched (intestine).
DR MIM; 606192; gene.
DR neXtProt; NX_Q6UXE8; -.
DR OpenTargets; ENSG00000168903; -.
DR PharmGKB; PA25464; -.
DR VEuPathDB; HostDB:ENSG00000168903; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163611; -.
DR HOGENOM; CLU_013137_22_0_1; -.
DR InParanoid; Q6UXE8; -.
DR OMA; CSIHLAE; -.
DR OrthoDB; 522383at2759; -.
DR PhylomeDB; Q6UXE8; -.
DR TreeFam; TF331083; -.
DR PathwayCommons; Q6UXE8; -.
DR SignaLink; Q6UXE8; -.
DR BioGRID-ORCS; 10917; 3 hits in 1066 CRISPR screens.
DR GenomeRNAi; 10917; -.
DR Pharos; Q6UXE8; Tdark.
DR PRO; PR:Q6UXE8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6UXE8; protein.
DR Bgee; ENSG00000168903; Expressed in jejunal mucosa and 107 other tissues.
DR Genevisible; Q6UXE8; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Immunoglobulin domain; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..466
FT /note="Butyrophilin-like protein 3"
FT /id="PRO_0000014540"
FT TOPO_DOM 18..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 138..218
FT /note="Ig-like V-type"
FT DOMAIN 270..463
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT VAR_SEQ 158..227
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10429365"
FT /id="VSP_012716"
FT VAR_SEQ 269
FT /note="L -> LGMCHVLSLPHMVLPGPSLIHSLSLWTTLAAGWTGST (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:10429365"
FT /id="VSP_012717"
FT CONFLICT 340
FT /note="K -> R (in Ref. 2; AAQ88751)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 466 AA; 52251 MW; 00E451EDC19316DE CRC64;
MAFVLILVLS FYELVSGQWQ VTGPGKFVQA LVGEDAVFSC SLFPETSAEA MEVRFFRNQF
HAVVHLYRDG EDWESKQMPQ YRGRTEFVKD SIAGGRVSLR LKNITPSDIG LYGCWFSSQI
YDEEATWELR VAALGSLPLI SIVGYVDGGI QLLCLSSGWF PQPTAKWKGP QGQDLSSDSR
ANADGYSLYD VEISIIVQEN AGSILCSIHL AEQSHEVESK VLIGETFFQP SPWRLASILL
GLLCGALCGV VMGMIIVFFK SKGKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK
LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQGFQAGK HYWEVDVGQN VGWYVGVCRD
DVDRGKNNVT LSPNNGYWVL RLTTEHLYFT FNPHFISLPP STPPTRVGVF LDYEGGTISF
FNTNDQSLIY TLLTCQFEGL LRPYIQHAMY DEEKGTPIFI CPVSWG
