ID   TOLIP_CHICK             Reviewed;         274 AA.
AC   Q5ZK05;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Toll-interacting protein;
GN   Name=TOLLIP; ORFNames=RCJMB04_14a3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the signaling pathway of IL-1 and Toll-like
CC       receptors. Inhibits cell activation by microbial products. Connects the
CC       ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8
CC       family adapter and thus mediating autophagic clearance of ubiquitin
CC       conjugates. The TOLLIP-dependent selective autophagy pathway plays an
CC       important role in clearance of cytotoxic polyQ proteins aggregates (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ATG8 family proteins (via AIM motifs), and
CC       ubiquitin (via CUE domain). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DOMAIN: Both ATG8-interaction motifs (AIM1 and AIM2) are required for
CC       the association with ATG8 family proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tollip family. {ECO:0000305}.
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DR   EMBL; AJ720279; CAG31938.1; -; mRNA.
DR   RefSeq; NP_001006471.1; NM_001006471.1.
DR   AlphaFoldDB; Q5ZK05; -.
DR   SMR; Q5ZK05; -.
DR   STRING; 9031.ENSGALP00000010809; -.
DR   PaxDb; Q5ZK05; -.
DR   GeneID; 423099; -.
DR   KEGG; gga:423099; -.
DR   CTD; 54472; -.
DR   VEuPathDB; HostDB:geneid_423099; -.
DR   eggNOG; ENOG502QWQA; Eukaryota.
DR   InParanoid; Q5ZK05; -.
DR   OrthoDB; 1219350at2759; -.
DR   PhylomeDB; Q5ZK05; -.
DR   PRO; PR:Q5ZK05; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; ISA:AgBase.
DR   GO; GO:0019900; F:kinase binding; ISA:AgBase.
DR   GO; GO:0035325; F:Toll-like receptor binding; ISA:AgBase.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0030855; P:epithelial cell differentiation; ISA:AgBase.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; ISS:UniProtKB.
DR   GO; GO:0036010; P:protein localization to endosome; ISA:AgBase.
DR   GO; GO:0007165; P:signal transduction; ISA:AgBase.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd04016; C2_Tollip; 1.
DR   CDD; cd14363; CUE_TOLIP; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR041799; TOLIP_CUE.
DR   InterPro; IPR037301; Tollip_C2.
DR   InterPro; IPR009060; UBA-like_sf.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF02845; CUE; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00546; CUE; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW   Reference proteome; Repeat.
FT   CHAIN           1..274
FT                   /note="Toll-interacting protein"
FT                   /id="PRO_0000384932"
FT   DOMAIN          35..152
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          229..272
FT                   /note="CUE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   MOTIF           133..136
FT                   /note="AIM1"
FT   MOTIF           151..154
FT                   /note="AIM2"
SQ   SEQUENCE   274 AA;  30540 MW;  A4618E78F5BB6469 CRC64;
     MATTVSTQRG PVYVGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGPMS TVGRLSITVV
     QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF
     DERAFSMDDR IAWTHITIPE SLKQGNVEDE WYSLSGRQGD DKEGMINLVM SYTSLPAAMM
     MQPQPVVLMP TVYQQGVGYV PIAGMPAVCN PDMVPVAIPP PAVNPQHLCN EEDLKSIQDM
     FPNMDREVIR SVLEAQRGNK NAAINSLLQM TEES