TOLQ_HAEIN
ID TOLQ_HAEIN Reviewed; 228 AA.
AC P43768; P94809;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Tol-Pal system protein TolQ {ECO:0000255|HAMAP-Rule:MF_02202};
GN Name=tolQ {ECO:0000255|HAMAP-Rule:MF_02202}; OrderedLocusNames=HI_0385;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-228.
RC STRAIN=1479;
RX PubMed=8921895; DOI=10.1016/0378-1119(96)00338-1;
RA Sen K., Sikkema D.J., Murphy T.F.;
RT "Isolation and characterization of the Haemophilus influenzae tolQ, tolR,
RT tolA and tolB genes.";
RL Gene 178:75-81(1996).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC Rule:MF_02202}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_02202}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02202, ECO:0000305}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_02202, ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ExbB/TolQ family. {ECO:0000255|HAMAP-
CC Rule:MF_02202, ECO:0000305}.
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DR EMBL; L42023; AAC22043.1; -; Genomic_DNA.
DR EMBL; U32470; AAC44594.1; -; Genomic_DNA.
DR PIR; I64064; I64064.
DR RefSeq; NP_438546.1; NC_000907.1.
DR RefSeq; WP_005649191.1; NC_000907.1.
DR AlphaFoldDB; P43768; -.
DR SMR; P43768; -.
DR STRING; 71421.HI_0385; -.
DR PRIDE; P43768; -.
DR EnsemblBacteria; AAC22043; AAC22043; HI_0385.
DR KEGG; hin:HI_0385; -.
DR PATRIC; fig|71421.8.peg.403; -.
DR eggNOG; COG0811; Bacteria.
DR HOGENOM; CLU_053325_2_2_6; -.
DR OMA; SWTYIFR; -.
DR PhylomeDB; P43768; -.
DR BioCyc; HINF71421:G1GJ1-400-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043213; P:bacteriocin transport; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IBA:GO_Central.
DR HAMAP; MF_02202; TolQ; 1.
DR InterPro; IPR002898; MotA_ExbB_proton_chnl.
DR InterPro; IPR014163; Tol-Pal_TolQ.
DR Pfam; PF01618; MotA_ExbB; 1.
DR TIGRFAMs; TIGR02796; tolQ; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..228
FT /note="Tol-Pal system protein TolQ"
FT /id="PRO_0000145824"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02202"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02202"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02202"
FT VARIANT 51
FT /note="R -> H (in strain: 1479)"
FT VARIANT 110
FT /note="M -> T (in strain: 1479)"
FT VARIANT 177
FT /note="I -> V (in strain: 1479)"
FT VARIANT 208
FT /note="G -> V (in strain: 1479)"
SQ SEQUENCE 228 AA; 25287 MW; 14AE319D2CB2A86B CRC64;
MTAELNFLDL FLKASIVVQL VIVILISFSI ISWAIIIQRS RILTNALKEA RTFEDRFWSG
EDLNKLYEGL SNRRDGLTGS EQIFCVGFKE FSRLKQVNPD APEAIIKGTM RAMNLAMNRE
IESLENRVPF LATVASVSPY IGLFGTVWGI MHAFMALSGA KQATLQMVAP GIAEALIATA
IGLFAAIPAV MAYNRLSLRV NAIEQDYGNF IDEFTTILHR QAFGKAPH
