BTNL9_HUMAN
ID BTNL9_HUMAN Reviewed; 535 AA.
AC Q6UXG8; A6NL42; Q6P660; Q96DM5;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Butyrophilin-like protein 9;
DE Flags: Precursor;
GN Name=BTNL9; ORFNames=UNQ1900/PRO4346;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6UXG8-3; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-17953245, EBI-10225815;
CC Q6UXG8-3; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-17953245, EBI-10827839;
CC Q6UXG8-3; Q07325: CXCL9; NbExp=3; IntAct=EBI-17953245, EBI-3911467;
CC Q6UXG8-3; O43169: CYB5B; NbExp=3; IntAct=EBI-17953245, EBI-1058710;
CC Q6UXG8-3; Q14507: EDDM3A; NbExp=3; IntAct=EBI-17953245, EBI-17953459;
CC Q6UXG8-3; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-17953245, EBI-6166686;
CC Q6UXG8-3; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-17953245, EBI-10266796;
CC Q6UXG8-3; Q6N075: MFSD5; NbExp=3; IntAct=EBI-17953245, EBI-3920969;
CC Q6UXG8-3; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-17953245, EBI-10317425;
CC Q6UXG8-3; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-17953245, EBI-11721828;
CC Q6UXG8-3; Q9NS64: RPRM; NbExp=3; IntAct=EBI-17953245, EBI-1052363;
CC Q6UXG8-3; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-17953245, EBI-10314552;
CC Q6UXG8-3; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-17953245, EBI-741850;
CC Q6UXG8-3; Q8N2H4: SYS1; NbExp=3; IntAct=EBI-17953245, EBI-13075176;
CC Q6UXG8-3; P01375: TNF; NbExp=3; IntAct=EBI-17953245, EBI-359977;
CC Q6UXG8-3; O00526: UPK2; NbExp=3; IntAct=EBI-17953245, EBI-10179682;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6UXG8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UXG8-2; Sequence=VSP_012720, VSP_012721;
CC Name=3;
CC IsoId=Q6UXG8-3; Sequence=VSP_012722, VSP_012723;
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY358358; AAQ88724.1; -; mRNA.
DR EMBL; AK057097; BAB71365.1; -; mRNA.
DR EMBL; AC008620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC091874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471165; EAW53724.1; -; Genomic_DNA.
DR EMBL; BC062459; AAH62459.1; -; mRNA.
DR CCDS; CCDS4460.2; -. [Q6UXG8-1]
DR CCDS; CCDS78104.1; -. [Q6UXG8-3]
DR RefSeq; NP_001295174.1; NM_001308245.1. [Q6UXG8-3]
DR RefSeq; NP_689760.2; NM_152547.4. [Q6UXG8-1]
DR RefSeq; XP_011532746.1; XM_011534444.2. [Q6UXG8-3]
DR AlphaFoldDB; Q6UXG8; -.
DR SMR; Q6UXG8; -.
DR BioGRID; 127506; 161.
DR IntAct; Q6UXG8; 16.
DR STRING; 9606.ENSP00000330200; -.
DR GlyGen; Q6UXG8; 3 sites.
DR iPTMnet; Q6UXG8; -.
DR PhosphoSitePlus; Q6UXG8; -.
DR BioMuta; BTNL9; -.
DR DMDM; 67462192; -.
DR jPOST; Q6UXG8; -.
DR MassIVE; Q6UXG8; -.
DR PaxDb; Q6UXG8; -.
DR PeptideAtlas; Q6UXG8; -.
DR PRIDE; Q6UXG8; -.
DR ProteomicsDB; 67612; -. [Q6UXG8-1]
DR ProteomicsDB; 67613; -. [Q6UXG8-2]
DR ProteomicsDB; 67614; -. [Q6UXG8-3]
DR Antibodypedia; 51014; 90 antibodies from 16 providers.
DR DNASU; 153579; -.
DR Ensembl; ENST00000327705.14; ENSP00000330200.9; ENSG00000165810.17. [Q6UXG8-1]
DR Ensembl; ENST00000376841.6; ENSP00000366037.2; ENSG00000165810.17. [Q6UXG8-3]
DR Ensembl; ENST00000491209.5; ENSP00000425424.1; ENSG00000165810.17. [Q6UXG8-2]
DR GeneID; 153579; -.
DR KEGG; hsa:153579; -.
DR MANE-Select; ENST00000327705.14; ENSP00000330200.9; NM_152547.5; NP_689760.2.
DR UCSC; uc003mmt.3; human. [Q6UXG8-1]
DR CTD; 153579; -.
DR DisGeNET; 153579; -.
DR GeneCards; BTNL9; -.
DR HGNC; HGNC:24176; BTNL9.
DR HPA; ENSG00000165810; Tissue enhanced (adipose tissue, breast).
DR neXtProt; NX_Q6UXG8; -.
DR OpenTargets; ENSG00000165810; -.
DR PharmGKB; PA134945306; -.
DR VEuPathDB; HostDB:ENSG00000165810; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160338; -.
DR HOGENOM; CLU_013137_22_0_1; -.
DR InParanoid; Q6UXG8; -.
DR OMA; VHLYQER; -.
DR PhylomeDB; Q6UXG8; -.
DR TreeFam; TF317532; -.
DR PathwayCommons; Q6UXG8; -.
DR Reactome; R-HSA-8851680; Butyrophilin (BTN) family interactions.
DR SignaLink; Q6UXG8; -.
DR BioGRID-ORCS; 153579; 7 hits in 1075 CRISPR screens.
DR ChiTaRS; BTNL9; human.
DR GenomeRNAi; 153579; -.
DR Pharos; Q6UXG8; Tbio.
DR PRO; PR:Q6UXG8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6UXG8; protein.
DR Bgee; ENSG00000165810; Expressed in right lung and 169 other tissues.
DR ExpressionAtlas; Q6UXG8; baseline and differential.
DR Genevisible; Q6UXG8; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..535
FT /note="Butyrophilin-like protein 9"
FT /id="PRO_0000014542"
FT TOPO_DOM 35..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..535
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 54..135
FT /note="Ig-like V-type"
FT DOMAIN 310..509
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT REGION 340..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 276..315
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 59..133
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 296..315
FT /note="EKLTAELEKLQTELDWRRAE -> GERGQGVLHAPAQVPKPAVI (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_012720"
FT VAR_SEQ 316..535
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_012721"
FT VAR_SEQ 320..344
FT /note="WRAAQKYAVDVTLDPASAHPSLEVS -> CFVLASHPPGEGIQAASNSTTTL
FT NA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_012722"
FT VAR_SEQ 345..535
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_012723"
FT VARIANT 511
FT /note="G -> R (in dbSNP:rs10068763)"
FT /id="VAR_049841"
SQ SEQUENCE 535 AA; 59716 MW; C692B773A6F05BDA CRC64;
MVDLSVSPDS LKPVSLTSSL VFLMHLLLLQ PGEPSSEVKV LGPEYPILAL VGEEVEFPCH
LWPQLDAQQM EIRWFRSQTF NVVHLYQEQQ ELPGRQMPAF RNRTKLVKDD IAYGSVVLQL
HSIIPSDKGT YGCRFHSDNF SGEALWELEV AGLGSDPHLS LEGFKEGGIQ LRLRSSGWYP
KPKVQWRDHQ GQCLPPEFEA IVWDAQDLFS LETSVVVRAG ALSNVSVSIQ NLLLSQKKEL
VVQIADVFVP GASAWKSAFV ATLPLLLVLA ALALGVLRKQ RRSREKLRKQ AEKRQEKLTA
ELEKLQTELD WRRAEGQAEW RAAQKYAVDV TLDPASAHPS LEVSEDGKSV SSRGAPPGPA
PGHPQRFSEQ TCALSLERFS AGRHYWEVHV GRRSRWFLGA CLAAVPRAGP ARLSPAAGYW
VLGLWNGCEY FVLAPHRVAL TLRVPPRRLG VFLDYEAGEL SFFNVSDGSH IFTFHDTFSG
ALCAYFRPRA HDGGEHPDPL TICPLPVRGT GVPEENDSDT WLQPYEPADP ALDWW
