TOLR_ECO57
ID TOLR_ECO57 Reviewed; 142 AA.
AC P0ABV8; P05829;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Tol-Pal system protein TolR {ECO:0000255|HAMAP-Rule:MF_02203};
GN Name=tolR {ECO:0000255|HAMAP-Rule:MF_02203};
GN OrderedLocusNames=Z0906, ECs0773;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. Required, with TolQ, for the
CC proton motive force-dependent activation of TolA and for TolA-Pal
CC interaction. {ECO:0000255|HAMAP-Rule:MF_02203}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_02203}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02203}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02203}.
CC -!- SIMILARITY: Belongs to the ExbD/TolR family. {ECO:0000255|HAMAP-
CC Rule:MF_02203, ECO:0000305}.
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DR EMBL; AE005174; AAG55074.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34196.1; -; Genomic_DNA.
DR PIR; E90725; E90725.
DR PIR; F85576; F85576.
DR RefSeq; NP_308800.1; NC_002695.1.
DR RefSeq; WP_000090097.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0ABV8; -.
DR SMR; P0ABV8; -.
DR STRING; 155864.EDL933_0818; -.
DR TCDB; 1.A.30.2.2; the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.
DR EnsemblBacteria; AAG55074; AAG55074; Z0906.
DR EnsemblBacteria; BAB34196; BAB34196; ECs_0773.
DR GeneID; 66670992; -.
DR GeneID; 917504; -.
DR KEGG; ece:Z0906; -.
DR KEGG; ecs:ECs_0773; -.
DR PATRIC; fig|386585.9.peg.892; -.
DR eggNOG; COG0848; Bacteria.
DR HOGENOM; CLU_085305_1_3_6; -.
DR OMA; YITEKAM; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR HAMAP; MF_02203; TolR; 1.
DR InterPro; IPR003400; ExbD.
DR InterPro; IPR014168; Tol-Pal_TolR.
DR PANTHER; PTHR30558; PTHR30558; 1.
DR Pfam; PF02472; ExbD; 1.
DR TIGRFAMs; TIGR02801; tolR; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="Tol-Pal system protein TolR"
FT /id="PRO_0000129141"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02203"
FT TOPO_DOM 39..142
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 15383 MW; 936FE0033172600B CRC64;
MARARGRGRR DLKSEINIVP LLDVLLVLLL IFMATAPIIT QSVEVDLPDA TESQAVSSND
NPPVIVEVSG IGQYTVVVEK DRLERLPPEQ VVAEVSSRFK ANPKTVFLIG GAKDVPYDEI
IKALNLLHSA GVKSVGLMTQ PI
