TOLR_ECOL6
ID TOLR_ECOL6 Reviewed; 142 AA.
AC P0ABV7; P05829;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Tol-Pal system protein TolR {ECO:0000255|HAMAP-Rule:MF_02203};
GN Name=tolR {ECO:0000255|HAMAP-Rule:MF_02203}; OrderedLocusNames=c0817;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. Required, with TolQ, for the
CC proton motive force-dependent activation of TolA and for TolA-Pal
CC interaction. {ECO:0000255|HAMAP-Rule:MF_02203}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_02203}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02203}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02203}.
CC -!- SIMILARITY: Belongs to the ExbD/TolR family. {ECO:0000255|HAMAP-
CC Rule:MF_02203, ECO:0000305}.
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DR EMBL; AE014075; AAN79290.1; -; Genomic_DNA.
DR RefSeq; WP_000090097.1; NC_004431.1.
DR AlphaFoldDB; P0ABV7; -.
DR SMR; P0ABV7; -.
DR STRING; 199310.c0817; -.
DR EnsemblBacteria; AAN79290; AAN79290; c0817.
DR GeneID; 66670992; -.
DR KEGG; ecc:c0817; -.
DR eggNOG; COG0848; Bacteria.
DR HOGENOM; CLU_085305_1_3_6; -.
DR OMA; YITEKAM; -.
DR BioCyc; ECOL199310:C0817-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR HAMAP; MF_02203; TolR; 1.
DR InterPro; IPR003400; ExbD.
DR InterPro; IPR014168; Tol-Pal_TolR.
DR PANTHER; PTHR30558; PTHR30558; 1.
DR Pfam; PF02472; ExbD; 1.
DR TIGRFAMs; TIGR02801; tolR; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="Tol-Pal system protein TolR"
FT /id="PRO_0000129142"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02203"
FT TOPO_DOM 39..142
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 15383 MW; 936FE0033172600B CRC64;
MARARGRGRR DLKSEINIVP LLDVLLVLLL IFMATAPIIT QSVEVDLPDA TESQAVSSND
NPPVIVEVSG IGQYTVVVEK DRLERLPPEQ VVAEVSSRFK ANPKTVFLIG GAKDVPYDEI
IKALNLLHSA GVKSVGLMTQ PI
