TOLR_HAEIN
ID TOLR_HAEIN Reviewed; 139 AA.
AC P43769;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Tol-Pal system protein TolR {ECO:0000255|HAMAP-Rule:MF_02203};
GN Name=tolR {ECO:0000255|HAMAP-Rule:MF_02203}; OrderedLocusNames=HI_0384;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1479;
RX PubMed=8921895; DOI=10.1016/0378-1119(96)00338-1;
RA Sen K., Sikkema D.J., Murphy T.F.;
RT "Isolation and characterization of the Haemophilus influenzae tolQ, tolR,
RT tolA and tolB genes.";
RL Gene 178:75-81(1996).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC Rule:MF_02203}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_02203}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02203}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02203}.
CC -!- SIMILARITY: Belongs to the ExbD/TolR family. {ECO:0000255|HAMAP-
CC Rule:MF_02203, ECO:0000305}.
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DR EMBL; L42023; AAC22042.1; -; Genomic_DNA.
DR EMBL; U32470; AAC44595.1; -; Genomic_DNA.
DR PIR; H64064; H64064.
DR RefSeq; NP_438545.1; NC_000907.1.
DR RefSeq; WP_005649190.1; NC_000907.1.
DR PDB; 2JWK; NMR; -; A/B=59-130.
DR PDB; 2JWL; NMR; -; A/B=59-130.
DR PDBsum; 2JWK; -.
DR PDBsum; 2JWL; -.
DR AlphaFoldDB; P43769; -.
DR BMRB; P43769; -.
DR SMR; P43769; -.
DR STRING; 71421.HI_0384; -.
DR EnsemblBacteria; AAC22042; AAC22042; HI_0384.
DR KEGG; hin:HI_0384; -.
DR PATRIC; fig|71421.8.peg.402; -.
DR eggNOG; COG0848; Bacteria.
DR HOGENOM; CLU_085305_1_3_6; -.
DR OMA; YITEKAM; -.
DR PhylomeDB; P43769; -.
DR BioCyc; HINF71421:G1GJ1-399-MON; -.
DR EvolutionaryTrace; P43769; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR HAMAP; MF_02203; TolR; 1.
DR InterPro; IPR003400; ExbD.
DR InterPro; IPR014168; Tol-Pal_TolR.
DR PANTHER; PTHR30558; PTHR30558; 1.
DR Pfam; PF02472; ExbD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Cell inner membrane;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..139
FT /note="Tol-Pal system protein TolR"
FT /id="PRO_0000129143"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02203"
FT STRAND 61..65
FT /evidence="ECO:0007829|PDB:2JWK"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:2JWK"
FT STRAND 71..75
FT /evidence="ECO:0007829|PDB:2JWK"
FT STRAND 78..83
FT /evidence="ECO:0007829|PDB:2JWK"
FT HELIX 85..98
FT /evidence="ECO:0007829|PDB:2JWK"
FT STRAND 104..108
FT /evidence="ECO:0007829|PDB:2JWK"
FT HELIX 114..126
FT /evidence="ECO:0007829|PDB:2JWK"
SQ SEQUENCE 139 AA; 15258 MW; 3A4D8FB633AF854F CRC64;
MARRQRKAIK SEINIVPFLD VLLVLVLIFM ATAPIISQSV QVELPDSVQS QEVSNEDKVP
VILEVAGIGK YAISIGGERQ EGLTEEMVTQ LSRQEFDKDN NTLFLVGGAK EVPYEEVIKA
LNLLHLAGIK SVGLMTNPI
