ID   TOLR_PSEAE              Reviewed;         146 AA.
AC   P50599;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Tol-Pal system protein TolR {ECO:0000255|HAMAP-Rule:MF_02203};
GN   Name=tolR {ECO:0000255|HAMAP-Rule:MF_02203}; OrderedLocusNames=PA0970;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAO;
RX   PubMed=8955385; DOI=10.1128/jb.178.24.7059-7068.1996;
RA   Dennis J.J., Lafontaine E.R., Sokol P.A.;
RT   "Identification and characterization of the tolQRA genes of Pseudomonas
RT   aeruginosa.";
RL   J. Bacteriol. 178:7059-7068(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_02203}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_02203}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02203}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_02203}.
CC   -!- SIMILARITY: Belongs to the ExbD/TolR family. {ECO:0000255|HAMAP-
CC       Rule:MF_02203, ECO:0000305}.
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DR   EMBL; U39558; AAC44659.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG04359.1; -; Genomic_DNA.
DR   PIR; D83525; D83525.
DR   RefSeq; NP_249661.1; NC_002516.2.
DR   RefSeq; WP_003086126.1; NZ_QZGE01000007.1.
DR   AlphaFoldDB; P50599; -.
DR   SMR; P50599; -.
DR   STRING; 287.DR97_967; -.
DR   PaxDb; P50599; -.
DR   PRIDE; P50599; -.
DR   DNASU; 882113; -.
DR   EnsemblBacteria; AAG04359; AAG04359; PA0970.
DR   GeneID; 882113; -.
DR   KEGG; pae:PA0970; -.
DR   PATRIC; fig|208964.12.peg.1008; -.
DR   PseudoCAP; PA0970; -.
DR   HOGENOM; CLU_085305_1_3_6; -.
DR   InParanoid; P50599; -.
DR   OMA; INHAVKI; -.
DR   PhylomeDB; P50599; -.
DR   BioCyc; PAER208964:G1FZ6-991-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   HAMAP; MF_02203; TolR; 1.
DR   InterPro; IPR003400; ExbD.
DR   InterPro; IPR014168; Tol-Pal_TolR.
DR   PANTHER; PTHR30558; PTHR30558; 1.
DR   Pfam; PF02472; ExbD; 1.
DR   TIGRFAMs; TIGR02801; tolR; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..146
FT                   /note="Tol-Pal system protein TolR"
FT                   /id="PRO_0000129144"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02203"
SQ   SEQUENCE   146 AA;  15788 MW;  1BD270601EEE8E70 CRC64;
     MARVRHKRKP VAEMNVVPYI DVMLVLLVIF MVTAPMLNQG VKVDLPKVSS EALPQDNNKQ
     VLTLSVKADG SYYWNVGSEV DTEKQTDSAV SLEQMTDAVT KIMSARPDTQ VFIRGDKAVN
     YGAVVGAMGA LQQAGVPNVG LITEAP