TOLR_SHIFL
ID TOLR_SHIFL Reviewed; 142 AA.
AC P0ABV9; P05829;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Tol-Pal system protein TolR {ECO:0000255|HAMAP-Rule:MF_02203};
GN Name=tolR {ECO:0000255|HAMAP-Rule:MF_02203};
GN OrderedLocusNames=SF0559, S0572;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. Required, with TolQ, for the
CC proton motive force-dependent activation of TolA and for TolA-Pal
CC interaction. {ECO:0000255|HAMAP-Rule:MF_02203}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_02203}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02203}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02203}.
CC -!- SIMILARITY: Belongs to the ExbD/TolR family. {ECO:0000255|HAMAP-
CC Rule:MF_02203, ECO:0000305}.
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DR EMBL; AE005674; AAN42203.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16076.1; -; Genomic_DNA.
DR RefSeq; NP_706496.1; NC_004337.2.
DR RefSeq; WP_000090097.1; NZ_WPGW01000046.1.
DR AlphaFoldDB; P0ABV9; -.
DR SMR; P0ABV9; -.
DR STRING; 198214.SF0559; -.
DR EnsemblBacteria; AAN42203; AAN42203; SF0559.
DR EnsemblBacteria; AAP16076; AAP16076; S0572.
DR GeneID; 1023523; -.
DR GeneID; 66670992; -.
DR KEGG; sfl:SF0559; -.
DR KEGG; sfx:S0572; -.
DR PATRIC; fig|198214.7.peg.648; -.
DR HOGENOM; CLU_085305_1_3_6; -.
DR OMA; YITEKAM; -.
DR OrthoDB; 1940365at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR HAMAP; MF_02203; TolR; 1.
DR InterPro; IPR003400; ExbD.
DR InterPro; IPR014168; Tol-Pal_TolR.
DR PANTHER; PTHR30558; PTHR30558; 1.
DR Pfam; PF02472; ExbD; 1.
DR TIGRFAMs; TIGR02801; tolR; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="Tol-Pal system protein TolR"
FT /id="PRO_0000129145"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02203"
FT TOPO_DOM 39..142
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 15383 MW; 936FE0033172600B CRC64;
MARARGRGRR DLKSEINIVP LLDVLLVLLL IFMATAPIIT QSVEVDLPDA TESQAVSSND
NPPVIVEVSG IGQYTVVVEK DRLERLPPEQ VVAEVSSRFK ANPKTVFLIG GAKDVPYDEI
IKALNLLHSA GVKSVGLMTQ PI
