BTNL9_MOUSE
ID BTNL9_MOUSE Reviewed; 536 AA.
AC Q8BJE2; B7ZC64; B9EKA9; Q80V04; Q811T7;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Butyrophilin-like protein 9;
DE Flags: Precursor;
GN Name=Btnl9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Meyer M., Trowsdale J.;
RT "Comparison of the butyrophilin cluster in human and mouse.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BJE2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BJE2-2; Sequence=VSP_042501, VSP_042502, VSP_042503;
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAX15495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY177687; AAO38197.1; -; mRNA.
DR EMBL; AK084528; BAC39210.1; -; mRNA.
DR EMBL; AL606829; CAX15495.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH466575; EDL33772.1; -; Genomic_DNA.
DR EMBL; BC025540; AAH25540.1; -; mRNA.
DR EMBL; BC150808; AAI50809.1; -; mRNA.
DR EMBL; BC151155; AAI51156.1; -; mRNA.
DR CCDS; CCDS24600.1; -. [Q8BJE2-1]
DR RefSeq; NP_766381.1; NM_172793.2. [Q8BJE2-1]
DR AlphaFoldDB; Q8BJE2; -.
DR SMR; Q8BJE2; -.
DR BioGRID; 231901; 1.
DR GlyGen; Q8BJE2; 3 sites.
DR iPTMnet; Q8BJE2; -.
DR PhosphoSitePlus; Q8BJE2; -.
DR jPOST; Q8BJE2; -.
DR MaxQB; Q8BJE2; -.
DR PaxDb; Q8BJE2; -.
DR PRIDE; Q8BJE2; -.
DR ProteomicsDB; 265391; -. [Q8BJE2-1]
DR ProteomicsDB; 265392; -. [Q8BJE2-2]
DR Antibodypedia; 51014; 90 antibodies from 16 providers.
DR DNASU; 237754; -.
DR Ensembl; ENSMUST00000046522; ENSMUSP00000046229; ENSMUSG00000040283. [Q8BJE2-1]
DR Ensembl; ENSMUST00000066531; ENSMUSP00000066598; ENSMUSG00000040283. [Q8BJE2-2]
DR GeneID; 237754; -.
DR KEGG; mmu:237754; -.
DR UCSC; uc007ipu.1; mouse. [Q8BJE2-1]
DR UCSC; uc011xuc.1; mouse. [Q8BJE2-2]
DR CTD; 153579; -.
DR MGI; MGI:2442439; Btnl9.
DR VEuPathDB; HostDB:ENSMUSG00000040283; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160338; -.
DR HOGENOM; CLU_013137_22_2_1; -.
DR InParanoid; Q8BJE2; -.
DR OMA; VHLYQER; -.
DR OrthoDB; 522383at2759; -.
DR PhylomeDB; Q8BJE2; -.
DR TreeFam; TF331083; -.
DR Reactome; R-MMU-8851680; Butyrophilin (BTN) family interactions.
DR BioGRID-ORCS; 237754; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8BJE2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BJE2; protein.
DR Bgee; ENSMUSG00000040283; Expressed in epididymal fat pad and 138 other tissues.
DR ExpressionAtlas; Q8BJE2; baseline and differential.
DR Genevisible; Q8BJE2; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..536
FT /note="Butyrophilin-like protein 9"
FT /id="PRO_0000416100"
FT TOPO_DOM 36..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..536
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..149
FT /note="Ig-like V-type 1"
FT DOMAIN 152..241
FT /note="Ig-like V-type 2"
FT DOMAIN 307..506
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 59..133
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 173..227
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 245
FT /note="A -> AGLSTLITEIEQFIWEQAKTQCHQAGCRILEQGPILYLQFTAFPSST
FT VVNSAIVPDPTWSEGCTAVFMFCSYLAREAPTEDVTGHPKVQDIMMWGPRRSCFS (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_042501"
FT VAR_SEQ 300..306
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_042502"
FT VAR_SEQ 325..333
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_042503"
FT CONFLICT 122..123
FT /note="KV -> NL (in Ref. 5; AAI50809)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="D -> H (in Ref. 5; AAI50809)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="I -> T (in Ref. 5; AAI50809)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="Q -> R (in Ref. 5; AAI50809)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 536 AA; 60549 MW; 90C123ADE0B52DB7 CRC64;
MADFSVFLGF LKQIPRCLSI FFTYLLFLQL WEVNSDKVWV LGPEESILAR VGEAVEFPCR
LSSYQDAEHM EIRWFRAQVS NVVYLYQEPQ GRSSLQMAQF RNRTLFEAYD IAEGSVNLHI
LKVLPSDEGR YGCRFLSDNF SGEATWELEV AGSGSDPHIS LQGFSGEGIQ LQCSSSGWYP
KPKVQWRGHQ GQCLSPESEA ITQNAQGLFS LETSVIVRGG AHSNVSCIIQ NPLLPQKKEF
VIQIADVFLP RMSPWKKAFV GTLVVLPLSL IVLTMLALRY FYKLRSFQEK QVKQGEEVRE
KLQTELDWRR SEGQAEWRAA QQYAADVTLD PATAHPSLEV SNNGKTVSSR LGVPSIAAGD
PQRFSEQTCV LSRERFSSGR HYWEVHVGRR SRWFLGACLE SVERSGPARL SPAAGYWVMG
LWNRCEYFVL DPHRVALALR VPPRRIGVLL DYEAGKLSFF NVSDGSHIFS FTDTFSGALR
AYLRPRAHDG SEHPDPMTIC SLPVRGPQVL EENDNDNWLQ PYEPLDPAWA VNEAVS
