TOM1_CHICK
ID TOM1_CHICK Reviewed; 515 AA.
AC O12940; O12941;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Target of Myb protein 1;
DE Short=Tom-1;
GN Name=TOM1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=SPAFAS; TISSUE=Bone marrow;
RX PubMed=9135152; DOI=10.1093/emboj/16.6.1371;
RA Burk O., Worpenberg S., Haenig B., Klempnauer K.-H.;
RT "tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed
RT myelomonocytic cells.";
RL EMBO J. 16:1371-1380(1997).
CC -!- FUNCTION: May be involved in intracellular trafficking. Probable
CC association with membranes.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Tom-1A;
CC IsoId=O12940-1; Sequence=Displayed;
CC Name=2; Synonyms=Tom-1A;
CC IsoId=O12940-2; Sequence=VSP_003993, VSP_003994, VSP_003995;
CC -!- INDUCTION: Expression is cooperatively activated by MYB and CEBPG.
CC -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y08740; CAA69995.1; -; mRNA.
DR EMBL; Y08741; CAA69996.1; -; mRNA.
DR RefSeq; NP_990475.1; NM_205144.2. [O12940-1]
DR AlphaFoldDB; O12940; -.
DR SMR; O12940; -.
DR STRING; 9031.ENSGALP00000020470; -.
DR PaxDb; O12940; -.
DR PRIDE; O12940; -.
DR Ensembl; ENSGALT00000020498; ENSGALP00000020470; ENSGALG00000012552. [O12940-1]
DR Ensembl; ENSGALT00000088480; ENSGALP00000060965; ENSGALG00000012552. [O12940-2]
DR GeneID; 396049; -.
DR KEGG; gga:396049; -.
DR CTD; 10043; -.
DR VEuPathDB; HostDB:geneid_396049; -.
DR eggNOG; KOG1087; Eukaryota.
DR GeneTree; ENSGT00940000156865; -.
DR HOGENOM; CLU_043812_3_0_1; -.
DR InParanoid; O12940; -.
DR OMA; RETHRVS; -.
DR OrthoDB; 594067at2759; -.
DR PhylomeDB; O12940; -.
DR TreeFam; TF314105; -.
DR Reactome; R-GGA-6798695; Neutrophil degranulation.
DR PRO; PR:O12940; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000012552; Expressed in muscle tissue and 13 other tissues.
DR ExpressionAtlas; O12940; baseline and differential.
DR GO; GO:0005829; C:cytosol; ISS:AgBase.
DR GO; GO:0005769; C:early endosome; ISS:AgBase.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISS:AgBase.
DR GO; GO:0030276; F:clathrin binding; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR014645; TOM1.
DR InterPro; IPR002014; VHS_dom.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036948; TOM1; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; SSF48464; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..515
FT /note="Target of Myb protein 1"
FT /id="PRO_0000072627"
FT DOMAIN 20..152
FT /note="VHS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00218"
FT DOMAIN 215..303
FT /note="GAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00373"
FT REGION 166..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..347
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9135152"
FT /id="VSP_003993"
FT VAR_SEQ 348..388
FT /note="TLGSRSVSAGLHSLDTSGKLEEEFDMFAVTRGSSLAEQRRE -> MICYSCK
FT KGPGWRGNLMRASGRGFILLAWMDCFPQSAWIRW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9135152"
FT /id="VSP_003994"
FT VAR_SEQ 414..434
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9135152"
FT /id="VSP_003995"
SQ SEQUENCE 515 AA; 57024 MW; B66E5C1645352D01 CRC64;
MDFLLGNPFS SPVGQRIERA TDGSLRGEDW SLNMEICDII NETEEGPKDA FRAIKKRIVG
NKNFHEVMLA LTVLETCVKN CGHRFHILVA SQDFVESVLV RTILPKNNPP AIVHDKVLTL
IQSWADAFRS SPDLTGVVAV YEDLRRKGLE FPMTDLDMLS PIHTPRRSVY SSNSQSGQNS
PAVNSPQQME SILHPVTLPS GRDTSSNVPI TPTQEQIKKL RSELEVVNGN VKVMSEMLTE
LVPSQAETSD LELLQELNRT CRAMQQRVLE LIPRVQHEQL TEELLLINDN LNNVFLRHER
FERVRTGQPV KAPSEAENNL IDLRPSTPPA VRQPEVTNNL SSQLAGMTLG SRSVSAGLHS
LDTSGKLEEE FDMFAVTRGS SLAEQRREVK YEDPQATKGL AGALDARQQN TGAEESSASS
DGAQLTNWMM RQGMVPVPQA NFMEDIEKWL STDVGESEDG KGVTSEEFDK FLEERAKVAD
RLPTLSSSSA GTPVSPAAAS RHQKQAKEDD AMFAL
