TOM20_BOVIN
ID TOM20_BOVIN Reviewed; 145 AA.
AC A6H7B1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Mitochondrial import receptor subunit TOM20 homolog;
DE AltName: Full=Mitochondrial 20 kDa outer membrane protein;
DE AltName: Full=Outer mitochondrial membrane receptor Tom20;
GN Name=TOMM20;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Central component of the receptor complex responsible for the
CC recognition and translocation of cytosolically synthesized
CC mitochondrial preproteins. Together with TOM22 functions as the transit
CC peptide receptor at the surface of the mitochondrion outer membrane and
CC facilitates the movement of preproteins into the TOM40 translocation
CC pore (By similarity). Required for the translocation across the
CC mitochondrial outer membrane of cytochrome P450 monooxygenases.
CC {ECO:0000250, ECO:0000250|UniProtKB:Q62760}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). Interacts with TOM22. Interacts with APEX1 (By similarity).
CC Interacts with TBC1D21 (By similarity). {ECO:0000250|UniProtKB:Q15388,
CC ECO:0000250|UniProtKB:Q9DCC8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q15388}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation
CC and enhancement of mitophagy. Deubiquitinated by USP30.
CC {ECO:0000250|UniProtKB:Q15388}.
CC -!- SIMILARITY: Belongs to the Tom20 family. {ECO:0000305}.
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DR EMBL; BC146178; AAI46179.1; -; mRNA.
DR RefSeq; NP_001092653.1; NM_001099183.1.
DR AlphaFoldDB; A6H7B1; -.
DR BMRB; A6H7B1; -.
DR SMR; A6H7B1; -.
DR STRING; 9913.ENSBTAP00000000733; -.
DR PaxDb; A6H7B1; -.
DR PRIDE; A6H7B1; -.
DR Ensembl; ENSBTAT00000000733; ENSBTAP00000000733; ENSBTAG00000000562.
DR GeneID; 781575; -.
DR KEGG; bta:781575; -.
DR CTD; 9804; -.
DR VEuPathDB; HostDB:ENSBTAG00000000562; -.
DR VGNC; VGNC:55995; TOMM20.
DR eggNOG; KOG4056; Eukaryota.
DR GeneTree; ENSGT00390000011698; -.
DR HOGENOM; CLU_100000_0_0_1; -.
DR InParanoid; A6H7B1; -.
DR OMA; VGYCFYF; -.
DR OrthoDB; 1316067at2759; -.
DR TreeFam; TF106200; -.
DR Reactome; R-BTA-5205685; PINK1-PRKN Mediated Mitophagy.
DR Reactome; R-BTA-5689880; Ub-specific processing proteases.
DR Proteomes; UP000009136; Chromosome 28.
DR Bgee; ENSBTAG00000000562; Expressed in spermatocyte and 105 other tissues.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR GO; GO:0016031; P:tRNA import into mitochondrion; IBA:GO_Central.
DR Gene3D; 1.20.960.10; -; 1.
DR InterPro; IPR002056; MAS20.
DR InterPro; IPR022422; MAS20_rcpt_metazoan.
DR InterPro; IPR023392; Tom20_dom_sf.
DR PANTHER; PTHR12430; PTHR12430; 1.
DR Pfam; PF02064; MAS20; 1.
DR PIRSF; PIRSF037707; MAS20_rcpt; 1.
DR PRINTS; PR01989; EUOM20RECPTR.
DR PRINTS; PR00351; OM20RECEPTOR.
DR SUPFAM; SSF47157; SSF47157; 1.
DR TIGRFAMs; TIGR00985; 3a0801s04tom; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Phosphoprotein; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Ubl conjugation.
FT CHAIN 1..145
FT /note="Mitochondrial import receptor subunit TOM20 homolog"
FT /id="PRO_0000317743"
FT TOPO_DOM 1..6
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 135
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15388"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15388"
FT CROSSLNK 35
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q15388"
FT CROSSLNK 56
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q15388"
FT CROSSLNK 61
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q15388"
FT CROSSLNK 68
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q15388"
SQ SEQUENCE 145 AA; 16298 MW; 5153BD25AC5D9B3A CRC64;
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE RAGLSKLPDL
KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC GQPQQLLQVL QQTLPPPVFQ
MLLTKLPTIS QRIVSAQSLA EDDVE
