TOM20_CAEEL
ID TOM20_CAEEL Reviewed; 188 AA.
AC Q19766;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Mitochondrial import receptor subunit TOM20 homolog;
DE AltName: Full=Mitochondrial 20 kDa outer membrane protein;
DE AltName: Full=Outer mitochondrial membrane receptor TOM20;
DE AltName: Full=Translocase of outer mitochondrial membrane protein 20;
GN Name=tomm-20 {ECO:0000312|WormBase:F23H12.2};
GN ORFNames=F23H12.2 {ECO:0000312|WormBase:F23H12.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21264209; DOI=10.1371/journal.pone.0014507;
RA Billing O., Kao G., Naredi P.;
RT "Mitochondrial function is required for secretion of DAF-28/insulin in C.
RT elegans.";
RL PLoS ONE 6:E14507-E14507(2011).
CC -!- FUNCTION: Central component of the receptor complex responsible for the
CC recognition and translocation of cytosolically synthesized
CC mitochondrial preproteins (By similarity). Together with tomm-22
CC functions as the transit peptide receptor at the surface of the
CC mitochondrion outer membrane and facilitates the movement of
CC preproteins into the translocation pore (PubMed:21264209).
CC {ECO:0000250|UniProtKB:P35848, ECO:0000269|PubMed:21264209}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex). {ECO:0000250|UniProtKB:Q15388}.
CC -!- INTERACTION:
CC Q19766; P34453: prx-19; NbExp=3; IntAct=EBI-320312, EBI-320322;
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in impaired
CC mitochondrial homeostasis with the up-regulation of the mitochondrial
CC unfolded protein chaperone hsp-6 and impaired daf-28/insulin secretion.
CC {ECO:0000269|PubMed:21264209}.
CC -!- SIMILARITY: Belongs to the Tom20 family. {ECO:0000305}.
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DR EMBL; Z74472; CAA98945.1; -; Genomic_DNA.
DR PIR; T21317; T21317.
DR RefSeq; NP_506092.1; NM_073691.5.
DR AlphaFoldDB; Q19766; -.
DR SMR; Q19766; -.
DR BioGRID; 44714; 16.
DR DIP; DIP-26815N; -.
DR IntAct; Q19766; 2.
DR STRING; 6239.F23H12.2; -.
DR EPD; Q19766; -.
DR PaxDb; Q19766; -.
DR PeptideAtlas; Q19766; -.
DR EnsemblMetazoa; F23H12.2.1; F23H12.2.1; WBGene00009092.
DR GeneID; 179691; -.
DR KEGG; cel:CELE_F23H12.2; -.
DR UCSC; F23H12.2.1; c. elegans.
DR CTD; 179691; -.
DR WormBase; F23H12.2; CE05705; WBGene00009092; tomm-20.
DR eggNOG; KOG4056; Eukaryota.
DR GeneTree; ENSGT00390000011698; -.
DR HOGENOM; CLU_100000_1_1_1; -.
DR InParanoid; Q19766; -.
DR OMA; HKRINAP; -.
DR OrthoDB; 1316067at2759; -.
DR PhylomeDB; Q19766; -.
DR SignaLink; Q19766; -.
DR PRO; PR:Q19766; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00009092; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0016031; P:tRNA import into mitochondrion; IBA:GO_Central.
DR Gene3D; 1.20.960.10; -; 1.
DR InterPro; IPR002056; MAS20.
DR InterPro; IPR022422; MAS20_rcpt_metazoan.
DR InterPro; IPR023392; Tom20_dom_sf.
DR PANTHER; PTHR12430; PTHR12430; 1.
DR Pfam; PF02064; MAS20; 1.
DR PRINTS; PR01989; EUOM20RECPTR.
DR PRINTS; PR00351; OM20RECEPTOR.
DR SUPFAM; SSF47157; SSF47157; 1.
DR TIGRFAMs; TIGR00985; 3a0801s04tom; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..188
FT /note="Mitochondrial import receptor subunit TOM20 homolog"
FT /id="PRO_0000051542"
FT TOPO_DOM 1..12
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 42..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 20426 MW; 5A7E0E00C408F2D3 CRC64;
MSDTILGFNK SNVVLAAGIA GAAFLGYCIY FDHKRINAPD YKDKIRQKRR AQAGAGGMAP
RRPAAAGNDA APDVTDPSQM QRFFLQEVQL GEELMAAGNV DEGAVHIANA VMLCGESQQL
LSIFQQTLSE DQFRAVVQQL PSTRERLAEM FGAKADEAEN EPPMVQYLGD GPPPAQIQEL
IDDTDDLE
