ID   TOM20_NEUCR             Reviewed;         181 AA.
AC   P35848; Q7RVE7;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Mitochondrial import receptor subunit tom20;
DE   AltName: Full=Mitochondrial 20 kDa outer membrane protein;
DE   AltName: Full=Protein mom19;
DE   AltName: Full=Translocase of outer membrane 20 kDa subunit;
GN   Name=tom20; Synonyms=mom19; ORFNames=NCU06632;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1661031; DOI=10.1126/science.1661031;
RA   Schneider H., Soellner T., Dietmeier N., Eckerskorn C., Lottspeich F.,
RA   Trueisch B., Neupert W., Pfanner K.;
RT   "Targeting of the master receptor MOM19 to mitochondria.";
RL   Science 254:1659-1662(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=7556061; DOI=10.1002/j.1460-2075.1995.tb00094.x;
RA   Mayer A., Nargans F.E., Neupert W., Lill R.;
RT   "MOM22 is a receptor for mitochondrial targeting sequences and cooperates
RT   with MOM19.";
RL   EMBO J. 14:4204-4211(1995).
CC   -!- FUNCTION: Central component of the receptor complex responsible for the
CC       recognition and translocation of cytosolically synthesized
CC       mitochondrial preproteins. Together with tom22 functions as the transit
CC       peptide receptor at the surface of the mitochondrion outer membrane and
CC       facilitates the movement of preproteins into the translocation pore.
CC       {ECO:0000269|PubMed:7556061}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex) which consists of at least 8
CC       different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and
CC       tom70).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Tom20 family. {ECO:0000305}.
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DR   EMBL; M80528; AAA33596.1; -; Genomic_DNA.
DR   EMBL; CM002239; EAA32584.1; -; Genomic_DNA.
DR   RefSeq; XP_961820.1; XM_956727.2.
DR   AlphaFoldDB; P35848; -.
DR   SMR; P35848; -.
DR   STRING; 5141.EFNCRP00000006321; -.
DR   PRIDE; P35848; -.
DR   EnsemblFungi; EAA32584; EAA32584; NCU06632.
DR   GeneID; 3877968; -.
DR   KEGG; ncr:NCU06632; -.
DR   VEuPathDB; FungiDB:NCU06632; -.
DR   HOGENOM; CLU_090411_2_0_1; -.
DR   InParanoid; P35848; -.
DR   OMA; VGYCFYF; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0016031; P:tRNA import into mitochondrion; IBA:GO_Central.
DR   Gene3D; 1.20.960.10; -; 1.
DR   InterPro; IPR002056; MAS20.
DR   InterPro; IPR023392; Tom20_dom_sf.
DR   PANTHER; PTHR12430; PTHR12430; 1.
DR   Pfam; PF02064; MAS20; 1.
DR   PIRSF; PIRSF037707; MAS20_rcpt; 1.
DR   PRINTS; PR00351; OM20RECEPTOR.
DR   SUPFAM; SSF47157; SSF47157; 1.
DR   TIGRFAMs; TIGR00985; 3a0801s04tom; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..181
FT                   /note="Mitochondrial import receptor subunit tom20"
FT                   /id="PRO_0000051548"
FT   TOPO_DOM        1..5
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..181
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   181 AA;  20229 MW;  31D83BC3BD9ABC5B CRC64;
     MPSQAVTYTT AAVAAVATGF LAYAVYFDYK RRNDPEFRRQ LRRSARRQAR QEKEYAELSQ
     QAQRQRIRQM VDEAKEEGFP TTSDEKEAYF LEQVQAGEIL GQDPTKAIDA SLAFYKALKV
     YPTPGDLISI YDKTVAKPIL DILAEMIAYD PSLKIGTNYT GGVDVAELMR EMASAPGVGL
     D