TOM20_SCHPO
ID TOM20_SCHPO Reviewed; 152 AA.
AC O14225;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Mitochondrial import receptor subunit tom20;
DE AltName: Full=Mitochondrial 20 kDa outer membrane protein;
DE AltName: Full=Translocase of outer membrane 20 kDa subunit;
GN Name=tom20; ORFNames=SPAC6F12.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Central component of the receptor complex responsible for the
CC recognition and translocation of cytosolically synthesized
CC mitochondrial preproteins. Together with tom22 functions as the transit
CC peptide receptor at the surface of the mitochondrion outer membrane and
CC facilitates the movement of preproteins into the translocation pore (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 8
CC different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and
CC tom70). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Tom20 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11091.1; -; Genomic_DNA.
DR PIR; T11658; T11658.
DR RefSeq; NP_593293.1; NM_001018723.2.
DR AlphaFoldDB; O14225; -.
DR SMR; O14225; -.
DR BioGRID; 279399; 3.
DR STRING; 4896.SPAC6F12.07.1; -.
DR MaxQB; O14225; -.
DR PaxDb; O14225; -.
DR PRIDE; O14225; -.
DR EnsemblFungi; SPAC6F12.07.1; SPAC6F12.07.1:pep; SPAC6F12.07.
DR GeneID; 2542959; -.
DR KEGG; spo:SPAC6F12.07; -.
DR PomBase; SPAC6F12.07; tom20.
DR VEuPathDB; FungiDB:SPAC6F12.07; -.
DR eggNOG; KOG4056; Eukaryota.
DR HOGENOM; CLU_090411_2_0_1; -.
DR InParanoid; O14225; -.
DR OMA; CFYSALK; -.
DR PhylomeDB; O14225; -.
DR PRO; PR:O14225; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; ISS:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; ISS:PomBase.
DR GO; GO:0016031; P:tRNA import into mitochondrion; IBA:GO_Central.
DR Gene3D; 1.20.960.10; -; 1.
DR InterPro; IPR002056; MAS20.
DR InterPro; IPR023392; Tom20_dom_sf.
DR PANTHER; PTHR12430; PTHR12430; 1.
DR Pfam; PF02064; MAS20; 1.
DR PIRSF; PIRSF037707; MAS20_rcpt; 1.
DR PRINTS; PR00351; OM20RECEPTOR.
DR SUPFAM; SSF47157; SSF47157; 1.
DR TIGRFAMs; TIGR00985; 3a0801s04tom; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..152
FT /note="Mitochondrial import receptor subunit tom20"
FT /id="PRO_0000051549"
FT TOPO_DOM 1..4
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 152 AA; 17529 MW; 5A3EC90178F61AD4 CRC64;
MRRSVIIGSL LATAAVGYAI YFDYKRRNDP HFRKTLKRRY KKVHEAKKQE EKLATKKFDI
TVEEALQVVA STPVPSSAEE KELFFMQQVA RGEQLFQQQP DNIKESAACF YSALKVYPQP
VELFAIYERT VPEPIMNLLR AMQAKESIPS VE
