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BTNLA_MOUSE
ID   BTNLA_MOUSE             Reviewed;         275 AA.
AC   Q9JK39; A2AB75; Q8C0U8;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Butyrophilin-like protein 10;
DE   Flags: Precursor;
GN   Name=Btnl10; Synonyms=Butr1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Spleen;
RA   Iaboni A., Davis S.J.;
RT   "A novel butyrophilin-like gene, BUTR-1, expressed in leukocytes.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9JK39-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9JK39-2; Sequence=VSP_043775;
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC       {ECO:0000305}.
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DR   EMBL; AF269232; AAF72554.1; -; mRNA.
DR   EMBL; AK029784; BAC26614.1; -; mRNA.
DR   EMBL; AL662809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS24753.1; -. [Q9JK39-1]
DR   CCDS; CCDS88163.1; -. [Q9JK39-2]
DR   RefSeq; NP_619619.2; NM_138678.2. [Q9JK39-1]
DR   RefSeq; XP_006532595.1; XM_006532532.3.
DR   RefSeq; XP_006532596.1; XM_006532533.3. [Q9JK39-2]
DR   AlphaFoldDB; Q9JK39; -.
DR   SMR; Q9JK39; -.
DR   GlyGen; Q9JK39; 3 sites.
DR   iPTMnet; Q9JK39; -.
DR   PhosphoSitePlus; Q9JK39; -.
DR   MaxQB; Q9JK39; -.
DR   PaxDb; Q9JK39; -.
DR   PeptideAtlas; Q9JK39; -.
DR   PRIDE; Q9JK39; -.
DR   ProteomicsDB; 265257; -. [Q9JK39-1]
DR   ProteomicsDB; 265258; -. [Q9JK39-2]
DR   DNASU; 192194; -.
DR   Ensembl; ENSMUST00000020792; ENSMUSP00000020792; ENSMUSG00000020490. [Q9JK39-1]
DR   Ensembl; ENSMUST00000069941; ENSMUSP00000063279; ENSMUSG00000020490. [Q9JK39-2]
DR   Ensembl; ENSMUST00000142499; ENSMUSP00000124234; ENSMUSG00000020490. [Q9JK39-2]
DR   GeneID; 192194; -.
DR   KEGG; mmu:192194; -.
DR   UCSC; uc007jco.1; mouse. [Q9JK39-2]
DR   UCSC; uc007jcp.1; mouse. [Q9JK39-1]
DR   CTD; 100129094; -.
DR   MGI; MGI:2182073; Btnl10.
DR   VEuPathDB; HostDB:ENSMUSG00000020490; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000163997; -.
DR   HOGENOM; CLU_013137_22_2_1; -.
DR   InParanoid; Q9JK39; -.
DR   OrthoDB; 522383at2759; -.
DR   TreeFam; TF331083; -.
DR   BioGRID-ORCS; 192194; 1 hit in 58 CRISPR screens.
DR   PRO; PR:Q9JK39; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q9JK39; protein.
DR   Bgee; ENSMUSG00000020490; Expressed in femorotibial joint and 15 other tissues.
DR   ExpressionAtlas; Q9JK39; baseline and differential.
DR   Genevisible; Q9JK39; MM.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..275
FT                   /note="Butyrophilin-like protein 10"
FT                   /id="PRO_0000417554"
FT   TOPO_DOM        30..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..275
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..140
FT                   /note="Ig-like V-type"
FT   CARBOHYD        59
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        123
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        54..128
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VAR_SEQ         233..275
FT                   /note="DTGFLAAVVKVSVSGAHTGNIGQSVQSHGSIIKSSESFSVKVP -> VTETY
FT                   LLASLSRRPLSTESGPALPLILTALGLVSAAIACAFGKCHKEEHKTNQEEEDPGARDEA
FT                   GLFHVSLSLDPETASPKLMVSEDQKSVKRLLFDQDVFPSSRRFNQDPCILAQERFEAGR
FT                   HYWEVEVGDRRAWILGVCLESLVREGRIPKSPQHGLWALEFYKKKLQALSYPRTCLSPP
FT                   EPLRRVGILLDFEAGQISFYNSTNGSLIYVFSGFSFSGPLQPFFCLWTHDPRPLTICSV
FT                   VTETKDTESSGDPGLPGDS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_043775"
FT   CONFLICT        232
FT                   /note="K -> Q (in Ref. 1; AAF72554)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   275 AA;  29549 MW;  AF603B24CC292E62 CRC64;
     MARAHPGDAT LPSILVSFIF LQLLTSGNGK SDFLVLGPPH PLLAIVGQDK ELPCKLSLNI
     SAEGMELRWY RDKPSSVVHV YKNGEDVYDE QMVEYKGRTS FNGSHVARGE AAVKIHNVTV
     FDNGTYHCVF KEYTSHSQAT LWLKVAGRGS SPRIRVTDTQ DKGIRAECTS AGWYPEPKVE
     WLDLKGQPVS AESHFSVSAS TGLVALLSIV TPQDTAVGGL TCSISNPLLP EKDTGFLAAV
     VKVSVSGAHT GNIGQSVQSH GSIIKSSESF SVKVP
 
 
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