BTNLA_MOUSE
ID BTNLA_MOUSE Reviewed; 275 AA.
AC Q9JK39; A2AB75; Q8C0U8;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Butyrophilin-like protein 10;
DE Flags: Precursor;
GN Name=Btnl10; Synonyms=Butr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RA Iaboni A., Davis S.J.;
RT "A novel butyrophilin-like gene, BUTR-1, expressed in leukocytes.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9JK39-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9JK39-2; Sequence=VSP_043775;
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
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DR EMBL; AF269232; AAF72554.1; -; mRNA.
DR EMBL; AK029784; BAC26614.1; -; mRNA.
DR EMBL; AL662809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24753.1; -. [Q9JK39-1]
DR CCDS; CCDS88163.1; -. [Q9JK39-2]
DR RefSeq; NP_619619.2; NM_138678.2. [Q9JK39-1]
DR RefSeq; XP_006532595.1; XM_006532532.3.
DR RefSeq; XP_006532596.1; XM_006532533.3. [Q9JK39-2]
DR AlphaFoldDB; Q9JK39; -.
DR SMR; Q9JK39; -.
DR GlyGen; Q9JK39; 3 sites.
DR iPTMnet; Q9JK39; -.
DR PhosphoSitePlus; Q9JK39; -.
DR MaxQB; Q9JK39; -.
DR PaxDb; Q9JK39; -.
DR PeptideAtlas; Q9JK39; -.
DR PRIDE; Q9JK39; -.
DR ProteomicsDB; 265257; -. [Q9JK39-1]
DR ProteomicsDB; 265258; -. [Q9JK39-2]
DR DNASU; 192194; -.
DR Ensembl; ENSMUST00000020792; ENSMUSP00000020792; ENSMUSG00000020490. [Q9JK39-1]
DR Ensembl; ENSMUST00000069941; ENSMUSP00000063279; ENSMUSG00000020490. [Q9JK39-2]
DR Ensembl; ENSMUST00000142499; ENSMUSP00000124234; ENSMUSG00000020490. [Q9JK39-2]
DR GeneID; 192194; -.
DR KEGG; mmu:192194; -.
DR UCSC; uc007jco.1; mouse. [Q9JK39-2]
DR UCSC; uc007jcp.1; mouse. [Q9JK39-1]
DR CTD; 100129094; -.
DR MGI; MGI:2182073; Btnl10.
DR VEuPathDB; HostDB:ENSMUSG00000020490; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163997; -.
DR HOGENOM; CLU_013137_22_2_1; -.
DR InParanoid; Q9JK39; -.
DR OrthoDB; 522383at2759; -.
DR TreeFam; TF331083; -.
DR BioGRID-ORCS; 192194; 1 hit in 58 CRISPR screens.
DR PRO; PR:Q9JK39; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9JK39; protein.
DR Bgee; ENSMUSG00000020490; Expressed in femorotibial joint and 15 other tissues.
DR ExpressionAtlas; Q9JK39; baseline and differential.
DR Genevisible; Q9JK39; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..275
FT /note="Butyrophilin-like protein 10"
FT /id="PRO_0000417554"
FT TOPO_DOM 30..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..140
FT /note="Ig-like V-type"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 54..128
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 233..275
FT /note="DTGFLAAVVKVSVSGAHTGNIGQSVQSHGSIIKSSESFSVKVP -> VTETY
FT LLASLSRRPLSTESGPALPLILTALGLVSAAIACAFGKCHKEEHKTNQEEEDPGARDEA
FT GLFHVSLSLDPETASPKLMVSEDQKSVKRLLFDQDVFPSSRRFNQDPCILAQERFEAGR
FT HYWEVEVGDRRAWILGVCLESLVREGRIPKSPQHGLWALEFYKKKLQALSYPRTCLSPP
FT EPLRRVGILLDFEAGQISFYNSTNGSLIYVFSGFSFSGPLQPFFCLWTHDPRPLTICSV
FT VTETKDTESSGDPGLPGDS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_043775"
FT CONFLICT 232
FT /note="K -> Q (in Ref. 1; AAF72554)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 275 AA; 29549 MW; AF603B24CC292E62 CRC64;
MARAHPGDAT LPSILVSFIF LQLLTSGNGK SDFLVLGPPH PLLAIVGQDK ELPCKLSLNI
SAEGMELRWY RDKPSSVVHV YKNGEDVYDE QMVEYKGRTS FNGSHVARGE AAVKIHNVTV
FDNGTYHCVF KEYTSHSQAT LWLKVAGRGS SPRIRVTDTQ DKGIRAECTS AGWYPEPKVE
WLDLKGQPVS AESHFSVSAS TGLVALLSIV TPQDTAVGGL TCSISNPLLP EKDTGFLAAV
VKVSVSGAHT GNIGQSVQSH GSIIKSSESF SVKVP