TOM22_BOVIN
ID TOM22_BOVIN Reviewed; 140 AA.
AC A6QPI6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Mitochondrial import receptor subunit TOM22 homolog;
DE AltName: Full=Translocase of outer membrane 22 kDa subunit homolog;
GN Name=TOMM22;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal brain;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Central receptor component of the translocase of the outer
CC membrane of mitochondria (TOM complex) responsible for the recognition
CC and translocation of cytosolically synthesized mitochondrial
CC preproteins. Together with the peripheral receptor TOM20 functions as
CC the transit peptide receptor and facilitates the movement of
CC preproteins into the translocation pore (By similarity). Required for
CC the translocation across the mitochondrial outer membrane of cytochrome
CC P450 monooxygenases (By similarity). {ECO:0000250|UniProtKB:Q75Q41,
CC ECO:0000250|UniProtKB:Q9NS69}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). Interacts with PPP2R2B and TOMM40 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- DOMAIN: The N-terminal domain (residues 1-60) is important for binding
CC to the unfolded mature imported proteins. Residues (47-69) of the
CC cytoplasmic domain interacts with TOMM20 while the C-terminal segment
CC (residues 61-80) binds presequence of preproteins. Requires the
CC transmembrane domain (TMD), a short segment (the import sequence) in
CC the cytoplasmic domain localizing separately from the TMD and the C-
CC tail signal in the C-terminal domain for efficient targeting and
CC integration into the TOM complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tom22 family. {ECO:0000305}.
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DR EMBL; BC149339; AAI49340.1; -; mRNA.
DR RefSeq; NP_001093805.1; NM_001100335.1.
DR AlphaFoldDB; A6QPI6; -.
DR SMR; A6QPI6; -.
DR STRING; 9913.ENSBTAP00000013405; -.
DR PaxDb; A6QPI6; -.
DR PeptideAtlas; A6QPI6; -.
DR PRIDE; A6QPI6; -.
DR Ensembl; ENSBTAT00000013405; ENSBTAP00000013405; ENSBTAG00000010157.
DR GeneID; 510780; -.
DR KEGG; bta:510780; -.
DR CTD; 56993; -.
DR VEuPathDB; HostDB:ENSBTAG00000010157; -.
DR VGNC; VGNC:49064; TOMM22.
DR eggNOG; KOG4111; Eukaryota.
DR GeneTree; ENSGT00390000016475; -.
DR HOGENOM; CLU_108175_1_0_1; -.
DR InParanoid; A6QPI6; -.
DR OMA; IKGLYAY; -.
DR OrthoDB; 1625053at2759; -.
DR TreeFam; TF106201; -.
DR Reactome; R-BTA-5205685; PINK1-PRKN Mediated Mitophagy.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000010157; Expressed in prostate gland and 103 other tissues.
DR ExpressionAtlas; A6QPI6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:Ensembl.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR InterPro; IPR005683; Tom22.
DR PANTHER; PTHR12504; PTHR12504; 1.
DR Pfam; PF04281; Tom22; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein;
KW Protein transport; Receptor; Reference proteome; Translocation;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..140
FT /note="Mitochondrial import receptor subunit TOM22 homolog"
FT /id="PRO_0000370709"
FT TOPO_DOM 1..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..140
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..48
FT /note="Import sequence; necessary for mitochondrion outer
FT membrane localization and integration in the TOM complex"
FT /evidence="ECO:0000250"
FT REGION 81..101
FT /note="TMD; necessary for mitochondrion outer membrane
FT localization and integration in the TOM complex"
FT /evidence="ECO:0000250"
FT REGION 121..140
FT /note="C-tail signal; necessary for mitochondrion outer
FT membrane localization and integration in the TOM complex"
FT /evidence="ECO:0000250"
FT COMPBIAS 26..40
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NS69"
FT MOD_RES 41
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NS69"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CPQ3"
SQ SEQUENCE 140 AA; 15292 MW; 36FEC51220BD3680 CRC64;
MAAAAAGPGA PLSADELLPK GDAEKPEEEL EEEDDEELDE TLSERLWGLT EMFPERVRSA
AGATFDLSLF VAQKMYRFSR AALWIGTTSF MILVLPVVFE TEKLQMEQQQ QLQQRQILLG
PNTGLSGGMP GALPSLPGKI
