TOM22_CAEEL
ID TOM22_CAEEL Reviewed; 109 AA.
AC O17287; A0A0M7RDR0;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Mitochondrial import receptor subunit TOM22 homolog {ECO:0000305};
GN Name=tomm-22 {ECO:0000312|WormBase:W10D9.5a};
GN ORFNames=W10D9.5 {ECO:0000312|WormBase:W10D9.5a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21264209; DOI=10.1371/journal.pone.0014507;
RA Billing O., Kao G., Naredi P.;
RT "Mitochondrial function is required for secretion of DAF-28/insulin in C.
RT elegans.";
RL PLoS ONE 6:E14507-E14507(2011).
CC -!- FUNCTION: Central receptor component of the translocase of the outer
CC membrane of mitochondria (TOM complex) responsible for the recognition
CC and translocation of cytosolically synthesized mitochondrial
CC preproteins (By similarity). Together with the peripheral receptor
CC tomm-20 functions as the transit peptide receptor and facilitates the
CC movement of preproteins into the translocation pore (PubMed:21264209).
CC {ECO:0000250|UniProtKB:Q9NS69, ECO:0000269|PubMed:21264209}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex). {ECO:0000250|UniProtKB:Q9NS69}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q9NS69}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9NS69}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:W10D9.5a};
CC IsoId=O17287-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:W10D9.5b};
CC IsoId=O17287-2; Sequence=VSP_058486;
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in impaired
CC mitochondrial homeostasis with the up-regulation of the mitochondrial
CC unfolded protein chaperone hsp-6 and impaired daf-28/insulin secretion.
CC {ECO:0000269|PubMed:21264209}.
CC -!- SIMILARITY: Belongs to the Tom22 family. {ECO:0000305}.
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DR EMBL; BX284602; CCD65583.1; -; Genomic_DNA.
DR EMBL; BX284602; CUR29997.1; -; Genomic_DNA.
DR PIR; F88021; F88021.
DR RefSeq; NP_001303802.1; NM_001316873.1.
DR RefSeq; NP_493741.1; NM_061340.5. [O17287-1]
DR AlphaFoldDB; O17287; -.
DR SMR; O17287; -.
DR DIP; DIP-26909N; -.
DR STRING; 6239.W10D9.5; -.
DR EPD; O17287; -.
DR PaxDb; O17287; -.
DR PeptideAtlas; O17287; -.
DR EnsemblMetazoa; W10D9.5a.1; W10D9.5a.1; WBGene00021133. [O17287-1]
DR EnsemblMetazoa; W10D9.5b.1; W10D9.5b.1; WBGene00021133. [O17287-2]
DR GeneID; 173436; -.
DR KEGG; cel:CELE_W10D9.5; -.
DR UCSC; W10D9.5.2; c. elegans. [O17287-1]
DR CTD; 173436; -.
DR WormBase; W10D9.5a; CE14794; WBGene00021133; tomm-22. [O17287-1]
DR WormBase; W10D9.5b; CE51123; WBGene00021133; tomm-22. [O17287-2]
DR eggNOG; KOG4111; Eukaryota.
DR GeneTree; ENSGT00390000016475; -.
DR HOGENOM; CLU_108175_1_1_1; -.
DR InParanoid; O17287; -.
DR OMA; IKGLYAY; -.
DR OrthoDB; 1625053at2759; -.
DR PhylomeDB; O17287; -.
DR PRO; PR:O17287; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00021133; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR InterPro; IPR005683; Tom22.
DR PANTHER; PTHR12504; PTHR12504; 1.
DR Pfam; PF04281; Tom22; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Protein transport; Receptor;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..109
FT /note="Mitochondrial import receptor subunit TOM22 homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437141"
FT TOPO_DOM 1..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 61..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..109
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT VAR_SEQ 1..94
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058486"
SQ SEQUENCE 109 AA; 12176 MW; 4DD8E83B43D0B6A9 CRC64;
MALVRDDFDD IPDSEIHETI VERIEGLGEM FPDALRSAVH STVDWSIWGV KGVFSLTKST
IWVVSTTSLI AFLPYIIEKE RSDLEKTQVA QQRQMLLGPS AAIQQAKTA
