TOM22_MACFA
ID TOM22_MACFA Reviewed; 142 AA.
AC Q4R3C7;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Mitochondrial import receptor subunit TOM22 homolog;
DE AltName: Full=Translocase of outer membrane 22 kDa subunit homolog;
GN Name=TOMM22; ORFNames=QtsA-17845;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Central receptor component of the translocase of the outer
CC membrane of mitochondria (TOM complex) responsible for the recognition
CC and translocation of cytosolically synthesized mitochondrial
CC preproteins. Together with the peripheral receptor TOM20 functions as
CC the transit peptide receptor and facilitates the movement of
CC preproteins into the translocation pore (By similarity). Required for
CC the translocation across the mitochondrial outer membrane of cytochrome
CC P450 monooxygenases (By similarity). {ECO:0000250|UniProtKB:Q75Q41,
CC ECO:0000250|UniProtKB:Q9NS69}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). Interacts with PPP2R2B and TOMM40 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- DOMAIN: The N-terminal domain (residues 1-62) is important for binding
CC to the unfolded mature imported proteins. Residues (49-71) of the
CC cytoplasmic domain interacts with TOMM20 while the C-terminal segment
CC (residues 63-82) binds presequence of preproteins. Requires the
CC transmembrane domain (TMD), a short segment (the import sequence) in
CC the cytoplasmic domain localizing separately from the TMD and the C-
CC tail signal in the C-terminal domain for efficient targeting and
CC integration into the TOM complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tom22 family. {ECO:0000305}.
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DR EMBL; AB179339; BAE02390.1; -; mRNA.
DR RefSeq; NP_001272071.1; NM_001285142.1.
DR AlphaFoldDB; Q4R3C7; -.
DR SMR; Q4R3C7; -.
DR STRING; 9541.XP_005567334.1; -.
DR Ensembl; ENSMFAT00000001053; ENSMFAP00000026871; ENSMFAG00000044855.
DR GeneID; 102137054; -.
DR CTD; 56993; -.
DR VEuPathDB; HostDB:ENSMFAG00000044855; -.
DR eggNOG; KOG4111; Eukaryota.
DR GeneTree; ENSGT00390000016475; -.
DR OMA; IKGLYAY; -.
DR OrthoDB; 1625053at2759; -.
DR Proteomes; UP000233100; Chromosome 10.
DR Bgee; ENSMFAG00000044855; Expressed in liver and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:Ensembl.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR InterPro; IPR005683; Tom22.
DR PANTHER; PTHR12504; PTHR12504; 1.
DR Pfam; PF04281; Tom22; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Phosphoprotein; Protein transport; Receptor; Reference proteome;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9NS69"
FT CHAIN 2..142
FT /note="Mitochondrial import receptor subunit TOM22 homolog"
FT /id="PRO_0000076107"
FT TOPO_DOM 2..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..142
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..50
FT /note="Import sequence; necessary for mitochondrion outer
FT membrane localization and integration in the TOM complex"
FT /evidence="ECO:0000250"
FT REGION 83..103
FT /note="TMD; necessary for mitochondrion outer membrane
FT localization and integration in the TOM complex"
FT /evidence="ECO:0000250"
FT REGION 123..142
FT /note="C-tail signal; necessary for mitochondrion outer
FT membrane localization and integration in the TOM complex"
FT /evidence="ECO:0000250"
FT COMPBIAS 28..42
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9NS69"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NS69"
FT MOD_RES 43
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NS69"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CPQ3"
SQ SEQUENCE 142 AA; 15522 MW; C957232F8420F34D CRC64;
MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG LTEMFPERVR
SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV FETEKLQMEQ QQQLQQRQIL
LGPNTGLSGG MPGALPSLPG KI
