TOM22_NEUCR
ID TOM22_NEUCR Reviewed; 154 AA.
AC Q07335; Q7RXS8;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Mitochondrial import receptor subunit tom22;
DE AltName: Full=MOM22 protein;
DE AltName: Full=Mitochondrial 22 kDa outer membrane protein;
DE AltName: Full=Translocase of outer membrane 22 kDa subunit;
GN Name=tom22; Synonyms=mom22; ORFNames=B13B7.130, NCU00431;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=74A;
RX PubMed=8348615; DOI=10.1016/0092-8674(93)80050-o;
RA Kiebler M., Keil P., Schneider H., van der Klei I.J., Pfanner N.,
RA Neupert W.;
RT "The mitochondrial receptor complex: a central role of MOM22 in mediating
RT preprotein transfer from receptors to the general insertion pore.";
RL Cell 74:483-492(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [4]
RP FUNCTION.
RX PubMed=7556061; DOI=10.1002/j.1460-2075.1995.tb00094.x;
RA Mayer A., Nargans F.E., Neupert W., Lill R.;
RT "MOM22 is a receptor for mitochondrial targeting sequences and cooperates
RT with MOM19.";
RL EMBO J. 14:4204-4211(1995).
CC -!- FUNCTION: Central component of the receptor complex responsible for the
CC recognition and translocation of cytosolically synthesized
CC mitochondrial preproteins. Together with tom20 functions as the transit
CC peptide receptor at the surface of the mitochondrion outer membrane and
CC facilitates the movement of preproteins into the translocation pore.
CC Docks tom20 and tom70 for interaction with the general TOM40 import
CC pore (GIP) complex. May regulate the TOM machinery organization,
CC stability and channel gating (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:7556061}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 8
CC different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and
CC tom70). Interacts with tom20 and tom70 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type II
CC membrane protein.
CC -!- DOMAIN: Its cytoplasmic domain associates with the cytoplasmic domains
CC of tom20 and tom70. Its intermembrane space domain provides a trans
CC binding site for presequences and the single membrane anchor is
CC required for a stable interaction between the GIP complex proteins (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tom22 family. {ECO:0000305}.
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DR EMBL; X71021; CAA50339.1; -; mRNA.
DR EMBL; BX908807; CAF05975.1; -; Genomic_DNA.
DR EMBL; CM002238; EAA27459.1; -; Genomic_DNA.
DR PIR; A40669; A40669.
DR RefSeq; XP_956695.1; XM_951602.2.
DR AlphaFoldDB; Q07335; -.
DR STRING; 5141.EFNCRP00000000419; -.
DR EnsemblFungi; EAA27459; EAA27459; NCU00431.
DR GeneID; 3872833; -.
DR KEGG; ncr:NCU00431; -.
DR VEuPathDB; FungiDB:NCU00431; -.
DR HOGENOM; CLU_094333_1_0_1; -.
DR InParanoid; Q07335; -.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:InterPro.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR InterPro; IPR005683; Tom22.
DR InterPro; IPR020951; Tom22_fungi.
DR PANTHER; PTHR12504; PTHR12504; 1.
DR Pfam; PF04281; Tom22; 1.
DR TIGRFAMs; TIGR00986; 3a0801s05tom22; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Receptor; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..154
FT /note="Mitochondrial import receptor subunit tom22"
FT /id="PRO_0000076111"
FT TOPO_DOM 1..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..154
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 154 AA; 16816 MW; C62EA2F3A7557439 CRC64;
MVQLTEVEDE HFQQPQVGPE EDDEDFTDTD SEISVDSDYE SQETFTDRLY ALRDMVSPTT
RGWFYHKYST TTNFVKSTLS FAGRAAWAVS VSGLLIGVPF AIAFAEDQNY AAMEQEARMR
ELGSDVLTAG GEGQAGTAEK TLAAIGGEGA RPAL
