ID   TOM22_SCHPO             Reviewed;         144 AA.
AC   O13813;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Mitochondrial import receptor subunit tom22;
DE   AltName: Full=Mitochondrial 22 kDa outer membrane protein;
DE   AltName: Full=Translocase of outer membrane 22 kDa subunit;
GN   Name=tom22; ORFNames=SPAC17H9.16;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Central component of the receptor complex responsible for the
CC       recognition and translocation of cytosolically synthesized
CC       mitochondrial preproteins. Together with tom20 functions as the transit
CC       peptide receptor at the surface of the mitochondrion outer membrane and
CC       facilitates the movement of preproteins into the translocation pore.
CC       Docks tom20 and tom70 for interaction with the general tom40 import
CC       pore (GIP) complex. May regulate the TOM machinery organization,
CC       stability and channel gating (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex) which consists of at least 8
CC       different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and
CC       tom70). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tom22 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB11225.1; -; Genomic_DNA.
DR   PIR; T37881; T37881.
DR   RefSeq; NP_593585.1; NM_001019017.2.
DR   AlphaFoldDB; O13813; -.
DR   SMR; O13813; -.
DR   BioGRID; 278745; 2.
DR   STRING; 4896.SPAC17H9.16.1; -.
DR   iPTMnet; O13813; -.
DR   MaxQB; O13813; -.
DR   PaxDb; O13813; -.
DR   EnsemblFungi; SPAC17H9.16.1; SPAC17H9.16.1:pep; SPAC17H9.16.
DR   GeneID; 2542276; -.
DR   KEGG; spo:SPAC17H9.16; -.
DR   PomBase; SPAC17H9.16; tom22.
DR   VEuPathDB; FungiDB:SPAC17H9.16; -.
DR   eggNOG; KOG4111; Eukaryota.
DR   HOGENOM; CLU_094333_1_0_1; -.
DR   InParanoid; O13813; -.
DR   OMA; VGNLVWI; -.
DR   PhylomeDB; O13813; -.
DR   PRO; PR:O13813; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; ISS:PomBase.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; ISS:PomBase.
DR   InterPro; IPR005683; Tom22.
DR   InterPro; IPR020951; Tom22_fungi.
DR   PANTHER; PTHR12504; PTHR12504; 1.
DR   Pfam; PF04281; Tom22; 1.
DR   TIGRFAMs; TIGR00986; 3a0801s05tom22; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Receptor; Reference proteome; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..144
FT                   /note="Mitochondrial import receptor subunit tom22"
FT                   /id="PRO_0000076112"
FT   TOPO_DOM        1..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..144
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   144 AA;  15912 MW;  8AA1823E28C6989E CRC64;
     MVKLEEVVDE TEVQNEQQTV IEKDQYIYAQ EDVEESDSDE SDFEGLEEET IIDRIAALKE
     IVPVTWRVKI ADGAKTATTG LSKLAQFGGK SMWVISTSAL LLGVPFMMSL EEEAQLTEYE
     KQIKDQRGAN EVIAPGATSG ALPQ