TOM3_ARATH
ID TOM3_ARATH Reviewed; 303 AA.
AC Q9ZUM2; Q8LF52; Q948X6;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Tobamovirus multiplication protein 3;
DE Short=AtTOM3;
GN Name=TOM3; OrderedLocusNames=At2g02180; ORFNames=F5O4.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, SUBUNIT,
RP INTERACTION WITH TMV-L REPLICASE, AND TOPOLOGY.
RC STRAIN=cv. Columbia;
RX PubMed=11836427; DOI=10.1128/jvi.76.5.2491-2497.2002;
RA Yamanaka T., Imai T., Satoh R., Kawashima A., Takahashi M., Tomita K.,
RA Kubota K., Meshi T., Naito S., Ishikawa M.;
RT "Complete inhibition of tobamovirus multiplication by simultaneous
RT mutations in two homologous host genes.";
RL J. Virol. 76:2491-2497(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Contributes to the intracellular multiplication of
CC tobamoviruses, probably being a membrane anchor promoting the formation
CC of the replication complex. {ECO:0000269|PubMed:11836427}.
CC -!- SUBUNIT: Constituent of tobamovirus replication complex. Interacts with
CC the helicase domain of tobamovirus-encoded replication proteins.
CC {ECO:0000269|PubMed:11836427}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: When associated with TOM1 disruption, reduced
CC efficiency of intracellular multiplication of tobamoviruses (e.g.
CC crucifer strain TMV-Cg), characterized by a reduced accumulation of
CC viral coat protein (CP) and reduced amplification of TMV-related RNAs.
CC {ECO:0000269|PubMed:11836427}.
CC -!- SIMILARITY: Belongs to the plant tobamovirus multiplication TOM1
CC protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM61605.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB036427; BAB64308.1; -; mRNA.
DR EMBL; AC005936; AAC97216.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC05557.1; -; Genomic_DNA.
DR EMBL; AK117222; BAC41898.1; -; mRNA.
DR EMBL; AY085048; AAM61605.1; ALT_INIT; mRNA.
DR PIR; H84433; H84433.
DR RefSeq; NP_027422.1; NM_126278.3.
DR AlphaFoldDB; Q9ZUM2; -.
DR STRING; 3702.AT2G02180.1; -.
DR PaxDb; Q9ZUM2; -.
DR PRIDE; Q9ZUM2; -.
DR ProteomicsDB; 234456; -.
DR EnsemblPlants; AT2G02180.1; AT2G02180.1; AT2G02180.
DR GeneID; 814749; -.
DR Gramene; AT2G02180.1; AT2G02180.1; AT2G02180.
DR KEGG; ath:AT2G02180; -.
DR Araport; AT2G02180; -.
DR TAIR; locus:2051663; AT2G02180.
DR eggNOG; ENOG502QQMF; Eukaryota.
DR HOGENOM; CLU_059685_0_0_1; -.
DR InParanoid; Q9ZUM2; -.
DR OMA; YASEMMM; -.
DR OrthoDB; 1067070at2759; -.
DR PhylomeDB; Q9ZUM2; -.
DR PRO; PR:Q9ZUM2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUM2; baseline and differential.
DR Genevisible; Q9ZUM2; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009705; C:plant-type vacuole membrane; ISS:UniProtKB.
DR GO; GO:0046786; P:viral replication complex formation and maintenance; IMP:TAIR.
DR InterPro; IPR040226; THH1/TOM1/TOM3.
DR InterPro; IPR009457; THH1/TOM1/TOM3_dom.
DR PANTHER; PTHR31142; PTHR31142; 1.
DR Pfam; PF06454; DUF1084; 1.
PE 1: Evidence at protein level;
KW Host-virus interaction; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Vacuole.
FT CHAIN 1..303
FT /note="Tobamovirus multiplication protein 3"
FT /id="PRO_0000423670"
FT TOPO_DOM 1..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 207
FT /note="G -> R (in Ref. 5; AAM61605)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 303 AA; 34989 MW; 0BFD5839E7922F8C CRC64;
MRIGGVEVTK FASEMMSSSS SSAVEMLNLK EASNWWSDVN ESPIWQDRIF HVLAVLYGIV
SLVAVIQLVR IQLRVPEYGW TTQKVFHFLN FVVNGVRAVV FVFRRNVQFM QPEILQHILL
DIPSLAFFTT YALLVLFWAE IYYQARAVST DGLRPSFFTI NAVVYVVQIA LWLVLWWKPV
RVMVILSKMF FAGVSLFAAL GFLLYGGRLF LMLQRFPVES KGRRKKLQEV GYVTTICFTC
FLIRCIMMCF AAFDEGANLD VLDHPILNFI YYLLVEILPS SLVLFILRKL PPKRGITQYH
QIR