ID   TOM40_BOVIN             Reviewed;         361 AA.
AC   Q1LZB5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Mitochondrial import receptor subunit TOM40 homolog;
DE   AltName: Full=Translocase of outer membrane 40 kDa subunit homolog;
GN   Name=TOMM40 {ECO:0000312|EMBL:AAI16106.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI16106.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI16106.1};
RC   TISSUE=Ascending colon {ECO:0000312|EMBL:AAI16106.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Channel-forming protein essential for import of protein
CC       precursors into mitochondria. Plays a role in the assembly of the
CC       mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I)
CC       by forming a complex with BCAP31 and mediating the translocation of
CC       Complex I components from the cytosol to the mitochondria.
CC       {ECO:0000250|UniProtKB:O96008}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex) which consists of at least 7
CC       different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC       TOMM70). Interacts with mitochondrial targeting sequences. Interacts
CC       with TIMM29; linking the TIM22 complex to the TOM complex. Forms a
CC       complex with BCAP31 (via C-terminus) which mediates the translocation
CC       of components of the mitochondrial membrane respiratory chain NADH
CC       dehydrogenase (Complex I) from the cytosol to the mitochondria (By
CC       similarity). Interacts (via N-terminus) with CYP1A1 (via mitochondrial
CC       targeting signal); this interaction is required for CYP1A1
CC       translocation across the mitochondrial outer membrane (By similarity).
CC       {ECO:0000250|UniProtKB:O96008, ECO:0000250|UniProtKB:Q75Q40}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:O96008}; Multi-pass membrane protein
CC       {ECO:0000255}. Note=Associates with the mitochondria-associated ER
CC       membrane via interaction with BCAP31. {ECO:0000250|UniProtKB:O96008}.
CC   -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000255}.
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DR   EMBL; BC116105; AAI16106.1; -; mRNA.
DR   RefSeq; NP_001068906.1; NM_001075438.1.
DR   AlphaFoldDB; Q1LZB5; -.
DR   SMR; Q1LZB5; -.
DR   STRING; 9913.ENSBTAP00000032188; -.
DR   PaxDb; Q1LZB5; -.
DR   PRIDE; Q1LZB5; -.
DR   Ensembl; ENSBTAT00000032251; ENSBTAP00000032188; ENSBTAG00000001781.
DR   GeneID; 510219; -.
DR   KEGG; bta:510219; -.
DR   CTD; 10452; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001781; -.
DR   VGNC; VGNC:49148; TOMM40.
DR   eggNOG; KOG3296; Eukaryota.
DR   GeneTree; ENSGT00390000003308; -.
DR   HOGENOM; CLU_054399_0_0_1; -.
DR   InParanoid; Q1LZB5; -.
DR   OMA; SHQFAMG; -.
DR   OrthoDB; 1346842at2759; -.
DR   TreeFam; TF106204; -.
DR   Reactome; R-BTA-5205685; PINK1-PRKN Mediated Mitophagy.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000001781; Expressed in retina and 105 other tissues.
DR   ExpressionAtlas; Q1LZB5; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0032592; C:integral component of mitochondrial membrane; IEA:Ensembl.
DR   GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR   CDD; cd07305; Porin3_Tom40; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR037930; Tom40.
DR   PANTHER; PTHR10802; PTHR10802; 1.
DR   Pfam; PF01459; Porin_3; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane beta strand; Transport.
FT   CHAIN           1..361
FT                   /note="Mitochondrial import receptor subunit TOM40 homolog"
FT                   /id="PRO_0000312685"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..37
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   361 AA;  37725 MW;  C3551E5CB8DDD23A CRC64;
     MGNVLAASSP PAGPPPPPAP PLVGLPPPPP SPPGFTLPPL GGGLGAGAGT GRGSERTPGT
     AAASAGGTAD DGACGCLPNP GTFEECHRKC KELFPIQMEG VKLTVNKGLS NHFQVNHTVA
     LSTIGESNYH FGVTYVGTKQ LSPTEAFPVL VGDMDNSGSL NAQVIHQLGP GLRSKMAIQT
     QQSKFVNWQV DGEYRGSDFT AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR
     PGEEGAVMSL AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSVS
     FGYQLDLPKA NLLFKGSVDS NWIVGATLEK KLPPLPLTLA LGAFLNHRKN KFQCGFGLTI
     G