ID   TOM40_NEUCR             Reviewed;         349 AA.
AC   P24391; Q7RVE2;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 140.
DE   RecName: Full=Mitochondrial import receptor subunit tom40;
DE   AltName: Full=Protein MOM38;
DE   AltName: Full=Translocase of outer membrane 40 kDa subunit;
GN   Name=tom40; Synonyms=mom38; ORFNames=B10H4.150, NCU01179;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2174514; DOI=10.1038/348610a0;
RA   Kiebler M., Pfaller R., Soellner T., Griffiths G., Horstmann H.,
RA   Pfanner N., Neupert W.;
RT   "Identification of a mitochondrial receptor complex required for
RT   recognition and membrane insertion of precursor proteins.";
RL   Nature 348:610-616(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [4]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=11402060; DOI=10.1083/jcb.153.6.1151;
RA   Ahting U., Thieffry M., Engelhardt H., Hegerl R., Neupert W.,
RA   Nussberger S.;
RT   "Tom40, the pore-forming component of the protein-conducting TOM channel in
RT   the outer membrane of mitochondria.";
RL   J. Cell Biol. 153:1151-1160(2001).
CC   -!- FUNCTION: Channel-forming protein essential for import of protein
CC       precursors into mitochondria. {ECO:0000269|PubMed:11402060}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex) which consists of at least 8
CC       different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and
CC       tom70). Interacts with mitochondrial targeting sequences.
CC       {ECO:0000269|PubMed:11402060}.
CC   -!- INTERACTION:
CC       P24391; Q07812: BAX; Xeno; NbExp=2; IntAct=EBI-1791540, EBI-516580;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X56883; CAA40205.1; -; mRNA.
DR   EMBL; AL670010; CAD21402.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA32309.1; -; Genomic_DNA.
DR   PIR; S13418; S13418.
DR   RefSeq; XP_961545.1; XM_956452.3.
DR   PDB; 5O8O; EM; 6.80 A; A=1-349.
DR   PDBsum; 5O8O; -.
DR   AlphaFoldDB; P24391; -.
DR   SMR; P24391; -.
DR   IntAct; P24391; 1.
DR   STRING; 5141.EFNCRP00000004357; -.
DR   PRIDE; P24391; -.
DR   EnsemblFungi; EAA32309; EAA32309; NCU01179.
DR   GeneID; 3877741; -.
DR   KEGG; ncr:NCU01179; -.
DR   VEuPathDB; FungiDB:NCU01179; -.
DR   HOGENOM; CLU_042174_0_0_1; -.
DR   InParanoid; P24391; -.
DR   OMA; SHQFAMG; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IEA:EnsemblFungi.
DR   CDD; cd07305; Porin3_Tom40; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR037930; Tom40.
DR   InterPro; IPR005686; Tom40_fungi.
DR   PANTHER; PTHR10802; PTHR10802; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   TIGRFAMs; TIGR00989; 3a0801s07tom40; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Porin; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   CHAIN           1..349
FT                   /note="Mitochondrial import receptor subunit tom40"
FT                   /id="PRO_0000051533"
SQ   SEQUENCE   349 AA;  38151 MW;  C17F11B576B36427 CRC64;
     MASFSTESPL AMLRDNAIYS SLSDAFNAFQ ERRKQFGLSN PGTIETIARE VQRDTLLTNY
     MFSGLRADVT KAFSLAPLFQ VSHQFAMGER LNPYAFAALY GTNQIFAQGN LDNEGALSTR
     FNYRWGDRTI TKTQFSIGGG QDMAQFEHEH LGDDFSASLK AINPSFLDGG LTGIFVGDYL
     QAVTPRLGLG LQAVWQRQGL TQGPDTAISY FARYKAGDWV ASAQLQAQGA LNTSFWKKLT
     DRVQAGVDMT LSVAPSQSMM GGLTKEGITT FGAKYDFRMS TFRAQIDSKG KLSCLLEKRL
     GAAPVTLTFA ADVDHVTQQA KLGMSVSIEA SDVDLQEQQE GAQSLNIPF