TOM40_RAT
ID TOM40_RAT Reviewed; 361 AA.
AC Q75Q40;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Mitochondrial import receptor subunit TOM40 homolog;
DE AltName: Full=Mitochondrial outer membrane protein of 38 kDa;
DE Short=OM38;
DE AltName: Full=Translocase of outer membrane 40 kDa subunit homolog;
GN Name=Tomm40; Synonyms=Tom40 {ECO:0000303|PubMed:19401463}, Tom40a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH TOMM20 AND
RP TOMM22.
RX PubMed=10980201; DOI=10.1074/jbc.m006558200;
RA Suzuki H., Okazawa Y., Komiya T., Saeki K., Mekada E., Kitada S., Ito A.,
RA Mihara K.;
RT "Characterization of rat TOM40, a central component of the preprotein
RT translocase of the mitochondrial outer membrane.";
RL J. Biol. Chem. 275:37930-37936(2000).
RN [2]
RP FUNCTION, AND INTERACTION WITH MITOCHONDRIAL TARGETING SEQUENCES.
RX PubMed=15347672; DOI=10.1074/jbc.m408604200;
RA Suzuki H., Kadowaki T., Maeda M., Sasaki H., Nabekura J., Sakaguchi M.,
RA Mihara K.;
RT "Membrane-embedded C-terminal segment of rat mitochondrial TOM40
RT constitutes protein-conducting pore with enriched beta-structure.";
RL J. Biol. Chem. 279:50619-50629(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH CYP1A1.
RX PubMed=19401463; DOI=10.1074/jbc.m109.007492;
RA Anandatheerthavarada H.K., Sepuri N.B., Avadhani N.G.;
RT "Mitochondrial targeting of cytochrome P450 proteins containing NH2-
RT terminal chimeric signals involves an unusual TOM20/TOM22 bypass
RT mechanism.";
RL J. Biol. Chem. 284:17352-17363(2009).
CC -!- FUNCTION: Channel-forming protein essential for import of protein
CC precursors into mitochondria (PubMed:10980201, PubMed:15347672,
CC PubMed:19401463). Plays a role in the assembly of the mitochondrial
CC membrane respiratory chain NADH dehydrogenase (Complex I) by forming a
CC complex with BCAP31 and mediating the translocation of Complex I
CC components from the cytosol to the mitochondria (By similarity).
CC {ECO:0000250|UniProtKB:O96008, ECO:0000269|PubMed:10980201,
CC ECO:0000269|PubMed:15347672, ECO:0000269|PubMed:19401463}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). Interacts with mitochondrial targeting sequences
CC (PubMed:10980201, PubMed:15347672). Interacts with TIMM29; linking the
CC TIM22 complex to the TOM complex (By similarity). Forms a complex with
CC BCAP31 (via C-terminus) which mediates the translocation of components
CC of the mitochondrial membrane respiratory chain NADH dehydrogenase
CC (Complex I) from the cytosol to the mitochondria (By similarity).
CC Interacts (via N-terminus) with CYP1A1 (via mitochondrial targeting
CC signal); this interaction is required for CYP1A1 translocation across
CC the mitochondrial outer membrane (PubMed:19401463).
CC {ECO:0000250|UniProtKB:O96008, ECO:0000269|PubMed:10980201,
CC ECO:0000269|PubMed:15347672, ECO:0000269|PubMed:19401463}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:O96008}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Associates with the mitochondria-associated ER
CC membrane via interaction with BCAP31. {ECO:0000250|UniProtKB:O96008}.
CC -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB162855; BAD11365.1; -; mRNA.
DR RefSeq; NP_997685.1; NM_212520.1.
DR AlphaFoldDB; Q75Q40; -.
DR SMR; Q75Q40; -.
DR STRING; 10116.ENSRNOP00000025281; -.
DR PhosphoSitePlus; Q75Q40; -.
DR jPOST; Q75Q40; -.
DR PaxDb; Q75Q40; -.
DR PRIDE; Q75Q40; -.
DR GeneID; 308416; -.
DR KEGG; rno:308416; -.
DR UCSC; RGD:1303022; rat.
DR CTD; 10452; -.
DR RGD; 1303022; Tomm40.
DR eggNOG; KOG3296; Eukaryota.
DR InParanoid; Q75Q40; -.
DR OrthoDB; 1346842at2759; -.
DR PhylomeDB; Q75Q40; -.
DR Reactome; R-RNO-5205685; PINK1-PRKN Mediated Mitophagy.
DR PRO; PR:Q75Q40; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0032592; C:integral component of mitochondrial membrane; ISO:RGD.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IDA:BHF-UCL.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; ISO:RGD.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IDA:BHF-UCL.
DR GO; GO:0005739; C:mitochondrion; IDA:BHF-UCL.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:cation channel activity; IDA:RGD.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0070678; F:preprotein binding; IDA:RGD.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IMP:BHF-UCL.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0051204; P:protein insertion into mitochondrial membrane; IMP:RGD.
DR GO; GO:0006626; P:protein targeting to mitochondrion; IDA:UniProtKB.
DR CDD; cd07305; Porin3_Tom40; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR InterPro; IPR037930; Tom40.
DR PANTHER; PTHR10802; PTHR10802; 1.
DR Pfam; PF01459; Porin_3; 1.
PE 1: Evidence at protein level;
KW Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Porin; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane beta strand; Transport.
FT CHAIN 1..361
FT /note="Mitochondrial import receptor subunit TOM40 homolog"
FT /id="PRO_0000051525"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..37
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 37919 MW; 1CC0FE0CBF845E89 CRC64;
MGNVLAASSP PAGPPPPPTP SLVGLPPPPP SPPGFTLPPL GGGLGTGSNA GRGSERTPGA
AASGAAASSN DGNCGCLPNP GTFEECHRKC KELFPVQMEG VKLTVNKGLS NRFQVTHTVA
LGTIGESNYH FGVTYVGTKQ LSPTEAFPVL VGDMDNSGSL NAQVIHQLSP GLRSKMAIQT
QQSKFVNWQV DGEYRGSDFT AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR
PGEKGTVMSL AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSAS
FGYQLDLPKA NFLFKGSVNS NWIVGATLEK KLPPLPLTLS LCAFLNHRKN KFLCGFGLTI
G
