TOM40_SCHPO
ID TOM40_SCHPO Reviewed; 344 AA.
AC O13656; O13655; Q7Z979; Q9URU0;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Probable mitochondrial import receptor subunit tom40;
DE AltName: Full=Translocase of outer membrane 40 kDa subunit;
GN Name=tom40; ORFNames=SPBC27B12.13, SPBC8D2.22;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Channel-forming protein essential for import of protein
CC precursors into mitochondria. {ECO:0000250}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 8
CC different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and
CC tom70). Interacts with mitochondrial targeting sequences.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA21445.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA21446.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB004538; BAA21445.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB004538; BAA21446.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CU329671; CAA16908.1; -; Genomic_DNA.
DR PIR; T40037; T40037.
DR RefSeq; NP_595546.2; NM_001021457.3.
DR AlphaFoldDB; O13656; -.
DR SMR; O13656; -.
DR STRING; 4896.SPBC27B12.13.1; -.
DR MaxQB; O13656; -.
DR PaxDb; O13656; -.
DR PRIDE; O13656; -.
DR EnsemblFungi; SPBC27B12.13.1; SPBC27B12.13.1:pep; SPBC27B12.13.
DR GeneID; 2540506; -.
DR KEGG; spo:SPBC27B12.13; -.
DR PomBase; SPBC27B12.13; tom40.
DR VEuPathDB; FungiDB:SPBC27B12.13; -.
DR eggNOG; KOG3296; Eukaryota.
DR HOGENOM; CLU_042174_0_0_1; -.
DR InParanoid; O13656; -.
DR OMA; SHQFAMG; -.
DR PhylomeDB; O13656; -.
DR PRO; PR:O13656; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; ISS:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015450; F:protein-transporting ATPase activity; ISS:PomBase.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; ISS:PomBase.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; ISS:PomBase.
DR CDD; cd07305; Porin3_Tom40; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR InterPro; IPR037930; Tom40.
DR InterPro; IPR005686; Tom40_fungi.
DR PANTHER; PTHR10802; PTHR10802; 1.
DR Pfam; PF01459; Porin_3; 1.
DR TIGRFAMs; TIGR00989; 3a0801s07tom40; 1.
PE 3: Inferred from homology;
KW Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Porin; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane beta strand; Transport.
FT CHAIN 1..344
FT /note="Probable mitochondrial import receptor subunit
FT tom40"
FT /id="PRO_0000051534"
SQ SEQUENCE 344 AA; 37553 MW; B6F654B386523F60 CRC64;
MDYIQTLFTS VNQVGEKIDS YKSSLNLINP GTCENLSKEV SKDILLSNYA FTGVRADVTK
GFCTSPWFTV SHAFALGSQV LPPYSFSTMF GGEPLFLRGS VDNDGAVQAM LNCTWNSNVL
SKVQMQLSNG AVPNMCQIEH DHKGKDFSFS FKAMNPWYEE KLTGIYIISL LQSVTPKLSL
GVEALWQKPS SSIGPEEATL SYMTRYNAAD WIATAHLNGS QGDVTATFWR KLSPKVEAGV
ECQLSPVGLN HSAALMTGPK PEGLTSVGVK YEFAQSIYRG QVDSKGRVGV YLERRLAPAI
TLAFSSELDH PNRNAKVGLG LSLELPGSDE MIQQQQQQLA AQTA
