ID   TOM40_XENLA             Reviewed;         336 AA.
AC   Q7ZTM6;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Mitochondrial import receptor subunit TOM40 homolog;
DE   AltName: Full=Translocase of outer membrane 40 kDa subunit homolog;
GN   Name=tomm40;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Channel-forming protein essential for import of protein
CC       precursors into mitochondria. {ECO:0000250|UniProtKB:O96008}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex). Interacts with mitochondrial
CC       targeting sequences (By similarity). {ECO:0000250|UniProtKB:O96008}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:O96008}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000305}.
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DR   EMBL; BC044706; AAH44706.1; -; mRNA.
DR   RefSeq; NP_001080609.1; NM_001087140.1.
DR   AlphaFoldDB; Q7ZTM6; -.
DR   SMR; Q7ZTM6; -.
DR   GeneID; 380301; -.
DR   KEGG; xla:380301; -.
DR   CTD; 380301; -.
DR   Xenbase; XB-GENE-995156; tomm40.L.
DR   OMA; ISGRMNH; -.
DR   OrthoDB; 1346842at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 380301; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR   CDD; cd07305; Porin3_Tom40; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR037930; Tom40.
DR   PANTHER; PTHR10802; PTHR10802; 1.
DR   Pfam; PF01459; Porin_3; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   CHAIN           1..336
FT                   /note="Mitochondrial import receptor subunit TOM40 homolog"
FT                   /id="PRO_0000051526"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..28
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  36129 MW;  324F6675DBC0A8CD CRC64;
     MGNVLAASSP APPPAGSPPV PGLVSVPPGF TMPPVAGLTP TPDKKEPQEE RLPNPGTFEE
     CHRKCKELFP IQMEGVKLIV NKGLSNYFQV NHTISLSTIG ESNYHFGATY VGTKQLGPAE
     AFPVLVGDFD NSGSLNGQII HQVTNNIRSK IALQTQQSKF VNWQLDTEYR GEDYTASVTL
     GNPDILVGSG ILVAHYLQSI TPSLALGGEL VYHRRPGEEG TVMSLAGRYT APSWTATLTL
     GQAGAHATYY HKANDQLQLG VEFEASARMQ DTSVSLGYQL DLPKANLLFK GSIDSNWIVG
     ATLEKKLPPL PLTLAMGAFL NHKKNKFQCG FGLTIG