ID   TOM40_XENTR             Reviewed;         336 AA.
AC   Q6P825;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Mitochondrial import receptor subunit TOM40 homolog;
DE   AltName: Full=Translocase of outer membrane 40 kDa subunit homolog;
GN   Name=tomm40;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Channel-forming protein essential for import of protein
CC       precursors into mitochondria. {ECO:0000250|UniProtKB:O96008}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex). Interacts with mitochondrial
CC       targeting sequences (By similarity). {ECO:0000250|UniProtKB:O96008}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:O96008}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000305}.
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DR   EMBL; BC061406; AAH61406.1; -; mRNA.
DR   RefSeq; NP_989125.1; NM_203794.1.
DR   AlphaFoldDB; Q6P825; -.
DR   SMR; Q6P825; -.
DR   STRING; 8364.ENSXETP00000036133; -.
DR   PaxDb; Q6P825; -.
DR   DNASU; 394730; -.
DR   GeneID; 394730; -.
DR   KEGG; xtr:394730; -.
DR   CTD; 10452; -.
DR   Xenbase; XB-GENE-995150; tomm40.
DR   eggNOG; KOG3296; Eukaryota.
DR   InParanoid; Q6P825; -.
DR   OrthoDB; 1346842at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR   CDD; cd07305; Porin3_Tom40; 1.
DR   Gene3D; 2.40.160.10; -; 2.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR037930; Tom40.
DR   PANTHER; PTHR10802; PTHR10802; 1.
DR   Pfam; PF01459; Porin_3; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   CHAIN           1..336
FT                   /note="Mitochondrial import receptor subunit TOM40 homolog"
FT                   /id="PRO_0000051527"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..28
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  36039 MW;  2D0FD7B7A88BE30F CRC64;
     MGNVLAASSP APPAAGSPPA PGLVSVPPGF TMPPVAGLTP TPDKKETQED RLPNPGTFEE
     CHRKCKELFP IQMEGVKLTV NKGLSNYFQV NHTVSLSMIG ESNYHFGATY VGTKQLGPAE
     AFPVLVGDLD NSGSLNAQII HQVTSNVRSK IALQTQQSKF VNWQLDTEYR GEDFTAAVTL
     GNPDILVGSG ILVAHYLQSI TPSLALGGEL VYHRRPGEEG TVMSLAGRYT APNWTATLTL
     GQAGAHATYY HKANDQLQVG VEFEASTRMQ DTSVSFGYQL DLPKANLLFK GSVDSNWIVG
     ATLEKKLPPL PLTLAMGAFL NHKKNKFQCG FGLTIG