TOM5_ARATH
ID TOM5_ARATH Reviewed; 54 AA.
AC Q9SD80; P83431;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Mitochondrial import receptor subunit TOM5 homolog;
DE AltName: Full=Translocase of outer membrane 5 kDa subunit homolog;
GN Name=TOM5; OrderedLocusNames=At5g08040; ORFNames=F13G24.240;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:CAB62616.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000312|EMBL:CAB62616.1};
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2] {ECO:0000312|EMBL:AAR92288.1}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3] {ECO:0000312|EMBL:AAR92288.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia {ECO:0000312|EMBL:AAR92288.1};
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP PROTEIN SEQUENCE OF 2-13, SUBUNIT, AND SUBCELLULAR LOCATION.
RA Werhahn W., Jaensch L., Braun H.-P.;
RT "Identification of novel subunits of the TOM complex from Arabidopsis
RT thaliana.";
RL Plant Physiol. Biochem. 41:407-416(2003).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=14730085; DOI=10.1104/pp.103.033910;
RA Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L.,
RA Millar A.H., Whelan J.;
RT "A transcriptomic and proteomic characterization of the Arabidopsis
RT mitochondrial protein import apparatus and its response to mitochondrial
RT dysfunction.";
RL Plant Physiol. 134:777-789(2004).
CC -!- FUNCTION: A component of the complex responsible for the recognition
CC and translocation of cytosolically synthesized mitochondrial
CC preproteins. {ECO:0000305}.
CC -!- SUBUNIT: Forms part of the receptor complex that consists of at least 6
CC different proteins (TOM5, TOM6, TOM7, TOM20, TOM22/TOM9 and TOM40).
CC {ECO:0000269|Ref.4, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|Ref.4};
CC Single-pass membrane protein {ECO:0000269|Ref.4}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, flowers, young cotyledons and
CC leaves. {ECO:0000269|PubMed:14730085}.
CC -!- SIMILARITY: Belongs to the Tom5 family. {ECO:0000305}.
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DR EMBL; AL133421; CAB62616.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91237.1; -; Genomic_DNA.
DR EMBL; BT011252; AAR92288.1; -; mRNA.
DR PIR; T45629; T45629.
DR RefSeq; NP_196421.1; NM_120886.3.
DR AlphaFoldDB; Q9SD80; -.
DR STRING; 3702.AT5G08040.1; -.
DR PaxDb; Q9SD80; -.
DR PRIDE; Q9SD80; -.
DR ProteomicsDB; 234285; -.
DR DNASU; 830698; -.
DR EnsemblPlants; AT5G08040.1; AT5G08040.1; AT5G08040.
DR GeneID; 830698; -.
DR Gramene; AT5G08040.1; AT5G08040.1; AT5G08040.
DR KEGG; ath:AT5G08040; -.
DR Araport; AT5G08040; -.
DR TAIR; locus:2142838; AT5G08040.
DR eggNOG; ENOG502S78P; Eukaryota.
DR HOGENOM; CLU_214046_0_0_1; -.
DR InParanoid; Q9SD80; -.
DR OMA; HDEQKWA; -.
DR OrthoDB; 1622216at2759; -.
DR PhylomeDB; Q9SD80; -.
DR PRO; PR:Q9SD80; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9SD80; baseline and differential.
DR Genevisible; Q9SD80; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR034553; TOM5_viridi.
DR PANTHER; PTHR37251; PTHR37251; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.4"
FT CHAIN 2..54
FT /note="Mitochondrial import receptor subunit TOM5 homolog"
FT /id="PRO_0000218263"
FT TOPO_DOM 2..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..48
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
SQ SEQUENCE 54 AA; 6091 MW; 8DB3B77A2F0FC3A1 CRC64;
MVNNVVSIEK MKALWHSEVH DEQKWAVNMK LLRALGMFAG GVVLMRSYGD LMGV
