TOM5_HUMAN
ID TOM5_HUMAN Reviewed; 51 AA.
AC Q8N4H5; B2DG07; F6S928; Q5JRT7;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Mitochondrial import receptor subunit TOM5 homolog;
GN Name=TOMM5; Synonyms=C9orf105, TOM5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, AND
RP SUBCELLULAR LOCATION.
RX PubMed=18331822; DOI=10.1016/j.bbrc.2008.02.150;
RA Kato H., Mihara K.;
RT "Identification of Tom5 and Tom6 in the preprotein translocase complex of
RT human mitochondrial outer membrane.";
RL Biochem. Biophys. Res. Commun. 369:958-963(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-10, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). {ECO:0000269|PubMed:18331822}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:18331822}; Single-pass membrane protein
CC {ECO:0000269|PubMed:18331822}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N4H5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4H5-2; Sequence=VSP_046982;
CC Name=3;
CC IsoId=Q8N4H5-3; Sequence=VSP_046983;
CC -!- SIMILARITY: Belongs to the Tom5 family. {ECO:0000305}.
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DR EMBL; AB435233; BAG30953.1; -; mRNA.
DR EMBL; AL513165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034247; AAH34247.1; -; mRNA.
DR CCDS; CCDS43803.1; -. [Q8N4H5-1]
DR CCDS; CCDS47967.1; -. [Q8N4H5-3]
DR CCDS; CCDS47968.1; -. [Q8N4H5-2]
DR RefSeq; NP_001001790.1; NM_001001790.2. [Q8N4H5-1]
DR RefSeq; NP_001127956.1; NM_001134484.1. [Q8N4H5-2]
DR RefSeq; NP_001127957.1; NM_001134485.1. [Q8N4H5-3]
DR PDB; 7CK6; EM; 3.40 A; I/J=1-51.
DR PDB; 7CP9; EM; 3.00 A; A/B=1-51.
DR PDBsum; 7CK6; -.
DR PDBsum; 7CP9; -.
DR AlphaFoldDB; Q8N4H5; -.
DR SMR; Q8N4H5; -.
DR BioGRID; 135117; 114.
DR ComplexPortal; CPX-6121; TOM40 mitochondrial outer membrane translocase complex.
DR CORUM; Q8N4H5; -.
DR IntAct; Q8N4H5; 7.
DR STRING; 9606.ENSP00000438204; -.
DR GlyGen; Q8N4H5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N4H5; -.
DR PhosphoSitePlus; Q8N4H5; -.
DR BioMuta; TOMM5; -.
DR EPD; Q8N4H5; -.
DR jPOST; Q8N4H5; -.
DR MassIVE; Q8N4H5; -.
DR MaxQB; Q8N4H5; -.
DR PeptideAtlas; Q8N4H5; -.
DR PRIDE; Q8N4H5; -.
DR ProteomicsDB; 27920; -.
DR ProteomicsDB; 63112; -.
DR ProteomicsDB; 71934; -. [Q8N4H5-1]
DR TopDownProteomics; Q8N4H5-1; -. [Q8N4H5-1]
DR Antibodypedia; 62917; 20 antibodies from 10 providers.
DR DNASU; 401505; -.
DR Ensembl; ENST00000321301.7; ENSP00000313584.6; ENSG00000175768.13. [Q8N4H5-1]
DR Ensembl; ENST00000377773.9; ENSP00000367004.5; ENSG00000175768.13. [Q8N4H5-3]
DR Ensembl; ENST00000544379.1; ENSP00000438204.1; ENSG00000175768.13. [Q8N4H5-2]
DR GeneID; 401505; -.
DR KEGG; hsa:401505; -.
DR MANE-Select; ENST00000321301.7; ENSP00000313584.6; NM_001001790.3; NP_001001790.1.
DR UCSC; uc004aaf.4; human. [Q8N4H5-1]
DR CTD; 401505; -.
DR DisGeNET; 401505; -.
DR GeneCards; TOMM5; -.
DR HGNC; HGNC:31369; TOMM5.
DR HPA; ENSG00000175768; Low tissue specificity.
DR MIM; 616169; gene.
DR neXtProt; NX_Q8N4H5; -.
DR OpenTargets; ENSG00000175768; -.
DR PharmGKB; PA164726670; -.
DR VEuPathDB; HostDB:ENSG00000175768; -.
DR eggNOG; ENOG502S99E; Eukaryota.
DR GeneTree; ENSGT00940000163364; -.
DR HOGENOM; CLU_182400_1_0_1; -.
DR InParanoid; Q8N4H5; -.
DR OMA; DCETSRE; -.
DR OrthoDB; 1642023at2759; -.
DR PhylomeDB; Q8N4H5; -.
DR TreeFam; TF333449; -.
DR PathwayCommons; Q8N4H5; -.
DR Reactome; R-HSA-1268020; Mitochondrial protein import.
DR Reactome; R-HSA-5205685; PINK1-PRKN Mediated Mitophagy.
DR SignaLink; Q8N4H5; -.
DR SIGNOR; Q8N4H5; -.
DR BioGRID-ORCS; 401505; 8 hits in 1074 CRISPR screens.
DR ChiTaRS; TOMM5; human.
DR GenomeRNAi; 401505; -.
DR Pharos; Q8N4H5; Tdark.
DR PRO; PR:Q8N4H5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8N4H5; protein.
DR Bgee; ENSG00000175768; Expressed in calcaneal tendon and 99 other tissues.
DR ExpressionAtlas; Q8N4H5; baseline and differential.
DR Genevisible; Q8N4H5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IC:ComplexPortal.
DR GO; GO:0006626; P:protein targeting to mitochondrion; IC:UniProtKB.
DR InterPro; IPR019603; Tom5.
DR InterPro; IPR029179; TOMM5_metazoa.
DR PANTHER; PTHR28436; PTHR28436; 1.
DR Pfam; PF10642; Tom5; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Isopeptide bond; Membrane;
KW Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Ubl conjugation.
FT CHAIN 1..51
FT /note="Mitochondrial import receptor subunit TOM5 homolog"
FT /id="PRO_0000230671"
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:25944712"
FT CROSSLNK 10
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 41..51
FT /note="TPFILKKLDSI -> SECLPGCDCETSGELTDGHPLTLRGHRGLRTELNGSG
FT EQGGCALKATGICAV (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046982"
FT VAR_SEQ 41
FT /note="T -> SECLPGCDCETSGELTDGHPLTLRGHRGLRTELNA (in isoform
FT 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_046983"
FT HELIX 13..40
FT /evidence="ECO:0007829|PDB:7CP9"
FT HELIX 42..45
FT /evidence="ECO:0007829|PDB:7CP9"
SQ SEQUENCE 51 AA; 6035 MW; 5B5204D78754B0FE CRC64;
MFRIEGLAPK LDPEEMKRKM REDVISSIRN FLIYVALLRV TPFILKKLDS I
