TOM5_MOUSE
ID TOM5_MOUSE Reviewed; 51 AA.
AC B1AXP6; B1AXP7; B1AXP8; B1AXP9;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Mitochondrial import receptor subunit TOM5 homolog {ECO:0000250|UniProtKB:Q8N4H5};
GN Name=Tomm5 {ECO:0000250|UniProtKB:Q8N4H5};
GN Synonyms=Tom5 {ECO:0000250|UniProtKB:Q8N4H5};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). {ECO:0000250|UniProtKB:Q8N4H5}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q8N4H5}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q8N4H5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=B1AXP6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B1AXP6-2; Sequence=VSP_052943;
CC Name=3;
CC IsoId=B1AXP6-3; Sequence=VSP_052944;
CC Name=4;
CC IsoId=B1AXP6-4; Sequence=VSP_052945;
CC -!- SIMILARITY: Belongs to the Tom5 family. {ECO:0000255}.
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DR EMBL; AL824706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38751.1; -. [B1AXP6-1]
DR CCDS; CCDS51172.1; -. [B1AXP6-3]
DR RefSeq; NP_001093145.1; NM_001099675.1. [B1AXP6-1]
DR RefSeq; NP_001128118.1; NM_001134646.1. [B1AXP6-3]
DR AlphaFoldDB; B1AXP6; -.
DR SMR; B1AXP6; -.
DR STRING; 10090.ENSMUSP00000103438; -.
DR iPTMnet; B1AXP6; -.
DR PhosphoSitePlus; B1AXP6; -.
DR MaxQB; B1AXP6; -.
DR PaxDb; B1AXP6; -.
DR PeptideAtlas; B1AXP6; -.
DR PRIDE; B1AXP6; -.
DR ProteomicsDB; 259492; -. [B1AXP6-1]
DR ProteomicsDB; 259493; -. [B1AXP6-2]
DR ProteomicsDB; 259494; -. [B1AXP6-3]
DR ProteomicsDB; 259495; -. [B1AXP6-4]
DR Antibodypedia; 62917; 20 antibodies from 10 providers.
DR Ensembl; ENSMUST00000107807; ENSMUSP00000103437; ENSMUSG00000078713. [B1AXP6-2]
DR Ensembl; ENSMUST00000107808; ENSMUSP00000103438; ENSMUSG00000078713. [B1AXP6-3]
DR Ensembl; ENSMUST00000107809; ENSMUSP00000103439; ENSMUSG00000078713. [B1AXP6-4]
DR Ensembl; ENSMUST00000107810; ENSMUSP00000103440; ENSMUSG00000078713. [B1AXP6-1]
DR GeneID; 68512; -.
DR KEGG; mmu:68512; -.
DR UCSC; uc008ssh.1; mouse. [B1AXP6-1]
DR UCSC; uc012ddl.1; mouse. [B1AXP6-3]
DR CTD; 401505; -.
DR MGI; MGI:1915762; Tomm5.
DR VEuPathDB; HostDB:ENSMUSG00000078713; -.
DR eggNOG; ENOG502S99E; Eukaryota.
DR GeneTree; ENSGT00940000164197; -.
DR HOGENOM; CLU_182400_2_0_1; -.
DR InParanoid; B1AXP6; -.
DR OMA; DCETSRE; -.
DR OrthoDB; 1642023at2759; -.
DR PhylomeDB; B1AXP6; -.
DR Reactome; R-MMU-5205685; PINK1-PRKN Mediated Mitophagy.
DR BioGRID-ORCS; 68512; 5 hits in 69 CRISPR screens.
DR ChiTaRS; Tomm5; mouse.
DR PRO; PR:B1AXP6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; B1AXP6; protein.
DR Bgee; ENSMUSG00000078713; Expressed in morula and 58 other tissues.
DR Genevisible; B1AXP6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0006626; P:protein targeting to mitochondrion; IC:UniProtKB.
DR InterPro; IPR019603; Tom5.
DR InterPro; IPR029179; TOMM5_metazoa.
DR PANTHER; PTHR28436; PTHR28436; 1.
DR Pfam; PF10642; Tom5; 1.
PE 3: Inferred from homology;
KW Acetylation; Alternative splicing; Isopeptide bond; Membrane;
KW Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Ubl conjugation.
FT CHAIN 1..51
FT /note="Mitochondrial import receptor subunit TOM5 homolog"
FT /id="PRO_0000351151"
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8N4H5"
FT CROSSLNK 10
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N4H5"
FT VAR_SEQ 40..51
FT /note="VTPYILKKLDSI -> LHIS (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_052943"
FT VAR_SEQ 41..51
FT /note="TPYILKKLDSI -> KPGMVAHTFNPSTQKAELHIS (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_052944"
FT VAR_SEQ 41..51
FT /note="TPYILKKLDSI -> NQPGLQMEFQDRQGGYTEKSVLKQETFVMCFSACLYV
FT NHVPAVQKGALESLELESSWPLILHIS (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_052945"
SQ SEQUENCE 51 AA; 6037 MW; 43F11A266854B0FE CRC64;
MFRIEGLAPK LDPEEMKRKM REDVVSSIRN FLIYVALLRV TPYILKKLDS I
