ID   TOM6_ARATH              Reviewed;          54 AA.
AC   Q9XIA7; P83432;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Mitochondrial import receptor subunit TOM6 homolog;
DE   AltName: Full=Translocase of outer membrane 6 kDa subunit homolog;
GN   Name=TOM6; OrderedLocusNames=At1g49410; ORFNames=F13F21.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAG42015.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia {ECO:0000269|PubMed:11130712};
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia {ECO:0000269|PubMed:14593172};
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-12, SUBUNIT, AND SUBCELLULAR LOCATION.
RA   Werhahn W., Jaensch L., Braun H.-P.;
RT   "Identification of novel subunits of the TOM complex from Arabidopsis
RT   thaliana.";
RL   Plant Physiol. Biochem. 41:407-416(2003).
RN   [5]
RP   TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=14730085; DOI=10.1104/pp.103.033910;
RA   Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L.,
RA   Millar A.H., Whelan J.;
RT   "A transcriptomic and proteomic characterization of the Arabidopsis
RT   mitochondrial protein import apparatus and its response to mitochondrial
RT   dysfunction.";
RL   Plant Physiol. 134:777-789(2004).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA   Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA   Giglione C.;
RT   "Comparative large-scale characterisation of plant vs. mammal proteins
RT   reveals similar and idiosyncratic N-alpha acetylation features.";
RL   Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC   -!- FUNCTION: A component of the complex responsible for the recognition
CC       and translocation of cytosolically synthesized mitochondrial
CC       preproteins. {ECO:0000305}.
CC   -!- SUBUNIT: Forms part of the receptor complex that consists of at least 6
CC       different proteins (TOM5, TOM6, TOM7, TOM20, TOM22/TOM9 and TOM40).
CC       {ECO:0000269|Ref.4, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000269|PubMed:14730085, ECO:0000269|Ref.4}; Single-pass membrane
CC       protein {ECO:0000269|PubMed:14730085, ECO:0000269|Ref.4}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, flowers, young cotyledons and
CC       leaves. {ECO:0000269|PubMed:14730085}.
CC   -!- SIMILARITY: Belongs to the Tom6 family. {ECO:0000305}.
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DR   EMBL; AC007504; AAD43159.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32427.1; -; Genomic_DNA.
DR   EMBL; AF327425; AAG42015.1; -; mRNA.
DR   EMBL; AF324714; AAG40065.1; -; mRNA.
DR   EMBL; AF325059; AAG40411.1; -; mRNA.
DR   EMBL; AF339720; AAK00402.1; -; mRNA.
DR   EMBL; AY037189; AAK59774.1; -; mRNA.
DR   EMBL; BT002672; AAO11588.1; -; mRNA.
DR   PIR; E96530; E96530.
DR   RefSeq; NP_564545.1; NM_103831.5.
DR   AlphaFoldDB; Q9XIA7; -.
DR   SMR; Q9XIA7; -.
DR   BioGRID; 26590; 1.
DR   IntAct; Q9XIA7; 1.
DR   STRING; 3702.AT1G49410.1; -.
DR   iPTMnet; Q9XIA7; -.
DR   PaxDb; Q9XIA7; -.
DR   PRIDE; Q9XIA7; -.
DR   ProteomicsDB; 234457; -.
DR   EnsemblPlants; AT1G49410.1; AT1G49410.1; AT1G49410.
DR   GeneID; 841365; -.
DR   Gramene; AT1G49410.1; AT1G49410.1; AT1G49410.
DR   KEGG; ath:AT1G49410; -.
DR   Araport; AT1G49410; -.
DR   TAIR; locus:2010212; AT1G49410.
DR   eggNOG; ENOG502S7ED; Eukaryota.
DR   HOGENOM; CLU_188823_0_0_1; -.
DR   InParanoid; Q9XIA7; -.
DR   OMA; WVVIIRA; -.
DR   OrthoDB; 1634624at2759; -.
DR   PhylomeDB; Q9XIA7; -.
DR   PRO; PR:Q9XIA7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9XIA7; baseline and differential.
DR   Genevisible; Q9XIA7; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR034554; TOM6_plants.
DR   PANTHER; PTHR35999; PTHR35999; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..54
FT                   /note="Mitochondrial import receptor subunit TOM6 homolog"
FT                   /id="PRO_0000210819"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0007744|PubMed:22223895"
SQ   SEQUENCE   54 AA;  6265 MW;  827D4D5609969B66 CRC64;
     MFPGMFMRKP DKAEALKQLR THVALFGSWV VIIRAAPYVL SYFSDSKDEL KIDF