TOM6_HUMAN
ID TOM6_HUMAN Reviewed; 74 AA.
AC Q96B49; B2DG15; Q9UH52;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Mitochondrial import receptor subunit TOM6 homolog;
DE AltName: Full=Overexpressed breast tumor protein;
DE AltName: Full=Translocase of outer membrane 6 kDa subunit homolog;
GN Name=TOMM6; Synonyms=OBTP, TOM6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, AND
RP SUBCELLULAR LOCATION.
RX PubMed=18331822; DOI=10.1016/j.bbrc.2008.02.150;
RA Kato H., Mihara K.;
RT "Identification of Tom5 and Tom6 in the preprotein translocase complex of
RT human mitochondrial outer membrane.";
RL Biochem. Biophys. Res. Commun. 369:958-963(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver cancer;
RA Kok L.D., Au T.C., Fung K.P., Lee C.Y., Tsui S.K., Waye M.M.;
RT "Identification of a novel human over-expressed breast tumor protein in
RT hepatocellular carcinoma.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow, Prostate, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). {ECO:0000269|PubMed:18331822}.
CC -!- INTERACTION:
CC Q96B49; Q13520: AQP6; NbExp=3; IntAct=EBI-10826510, EBI-13059134;
CC Q96B49; Q96HA4-2: C1orf159; NbExp=3; IntAct=EBI-10826510, EBI-17586094;
CC Q96B49; P34810: CD68; NbExp=6; IntAct=EBI-10826510, EBI-2826276;
CC Q96B49; Q9HA82: CERS4; NbExp=3; IntAct=EBI-10826510, EBI-2622997;
CC Q96B49; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10826510, EBI-781551;
CC Q96B49; O14843: FFAR3; NbExp=3; IntAct=EBI-10826510, EBI-17762181;
CC Q96B49; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-10826510, EBI-12382569;
CC Q96B49; Q8TC24: SEC61A2; NbExp=3; IntAct=EBI-10826510, EBI-12238317;
CC Q96B49; Q14973: SLC10A1; NbExp=3; IntAct=EBI-10826510, EBI-3923031;
CC Q96B49; Q05940: SLC18A2; NbExp=3; IntAct=EBI-10826510, EBI-18036244;
CC Q96B49; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10826510, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:18331822}.
CC -!- SIMILARITY: Belongs to the Tom6 family. {ECO:0000305}.
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DR EMBL; AB435319; BAG30996.1; -; mRNA.
DR EMBL; AF216754; AAF25683.1; -; mRNA.
DR EMBL; AL365205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015975; AAH15975.1; -; mRNA.
DR EMBL; BC018624; AAH18624.1; -; mRNA.
DR EMBL; BC022274; AAH22274.1; -; mRNA.
DR CCDS; CCDS47424.1; -.
DR RefSeq; NP_001127965.1; NM_001134493.1.
DR PDB; 7CK6; EM; 3.40 A; E/F=1-74.
DR PDB; 7CP9; EM; 3.00 A; C/D=1-74.
DR PDBsum; 7CK6; -.
DR PDBsum; 7CP9; -.
DR AlphaFoldDB; Q96B49; -.
DR SMR; Q96B49; -.
DR BioGRID; 937002; 38.
DR ComplexPortal; CPX-6121; TOM40 mitochondrial outer membrane translocase complex.
DR CORUM; Q96B49; -.
DR IntAct; Q96B49; 14.
DR MINT; Q96B49; -.
DR STRING; 9606.ENSP00000381859; -.
DR iPTMnet; Q96B49; -.
DR PhosphoSitePlus; Q96B49; -.
DR BioMuta; TOMM6; -.
DR EPD; Q96B49; -.
DR jPOST; Q96B49; -.
DR MassIVE; Q96B49; -.
DR MaxQB; Q96B49; -.
DR PaxDb; Q96B49; -.
DR PeptideAtlas; Q96B49; -.
DR PRIDE; Q96B49; -.
DR ProteomicsDB; 76045; -.
DR TopDownProteomics; Q96B49; -.
DR Antibodypedia; 1581; 79 antibodies from 19 providers.
DR DNASU; 100188893; -.
DR Ensembl; ENST00000398881.4; ENSP00000381856.3; ENSG00000214736.8.
DR Ensembl; ENST00000398884.7; ENSP00000381859.3; ENSG00000214736.8.
DR GeneID; 100188893; -.
DR KEGG; hsa:100188893; -.
DR MANE-Select; ENST00000398881.4; ENSP00000381856.3; NM_001382294.1; NP_001369223.1.
DR UCSC; uc011dug.2; human.
DR CTD; 100188893; -.
DR DisGeNET; 100188893; -.
DR GeneCards; TOMM6; -.
DR HGNC; HGNC:34528; TOMM6.
DR HPA; ENSG00000214736; Low tissue specificity.
DR MIM; 616168; gene.
DR neXtProt; NX_Q96B49; -.
DR PharmGKB; PA164726679; -.
DR VEuPathDB; HostDB:ENSG00000214736; -.
DR eggNOG; ENOG502S9AX; Eukaryota.
DR GeneTree; ENSGT00390000002376; -.
DR HOGENOM; CLU_2687147_0_0_1; -.
DR InParanoid; Q96B49; -.
DR OMA; VMEWISS; -.
DR OrthoDB; 1571629at2759; -.
DR PhylomeDB; Q96B49; -.
DR TreeFam; TF330716; -.
DR PathwayCommons; Q96B49; -.
DR Reactome; R-HSA-1268020; Mitochondrial protein import.
DR Reactome; R-HSA-5205685; PINK1-PRKN Mediated Mitophagy.
DR SignaLink; Q96B49; -.
DR SIGNOR; Q96B49; -.
DR BioGRID-ORCS; 100188893; 14 hits in 1039 CRISPR screens.
DR ChiTaRS; TOMM6; human.
DR GenomeRNAi; 100188893; -.
DR Pharos; Q96B49; Tbio.
DR PRO; PR:Q96B49; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96B49; protein.
DR Bgee; ENSG00000214736; Expressed in right adrenal gland and 96 other tissues.
DR Genevisible; Q96B49; HS.
DR GO; GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IC:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IC:ComplexPortal.
DR InterPro; IPR029182; TOMM6.
DR PANTHER; PTHR15527; PTHR15527; 1.
DR Pfam; PF15184; TOM6p; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Protein transport; Reference proteome;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:25944712"
FT CHAIN 2..74
FT /note="Mitochondrial import receptor subunit TOM6 homolog"
FT /id="PRO_0000302856"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:25944712"
FT CONFLICT 16
FT /note="E -> K (in Ref. 2; AAF25683)"
FT /evidence="ECO:0000305"
FT TURN 17..19
FT /evidence="ECO:0007829|PDB:7CP9"
FT HELIX 20..32
FT /evidence="ECO:0007829|PDB:7CP9"
FT HELIX 42..59
FT /evidence="ECO:0007829|PDB:7CP9"
SQ SEQUENCE 74 AA; 8002 MW; 805462C0444865FD CRC64;
MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG LFAAGVWLAR
NLSDIDLMAP QPGV
