TOM6_MOUSE
ID TOM6_MOUSE Reviewed; 74 AA.
AC Q9CQN3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Mitochondrial import receptor subunit TOM6 homolog;
DE AltName: Full=Overexpressed breast tumor protein homolog;
DE AltName: Full=Translocase of outer membrane 6 kDa subunit homolog;
GN Name=Tomm6; Synonyms=Obtp, Tom6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tom6 family. {ECO:0000305}.
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DR EMBL; AK003291; BAB22694.1; -; mRNA.
DR EMBL; AK010470; BAB26963.1; -; mRNA.
DR EMBL; AK019199; BAB31597.1; -; mRNA.
DR EMBL; BC021590; AAH21590.1; -; mRNA.
DR EMBL; BC037589; AAH37589.1; -; mRNA.
DR CCDS; CCDS37643.1; -.
DR RefSeq; NP_001158201.1; NM_001164729.1.
DR RefSeq; NP_079641.1; NM_025365.3.
DR AlphaFoldDB; Q9CQN3; -.
DR SMR; Q9CQN3; -.
DR STRING; 10090.ENSMUSP00000108926; -.
DR PhosphoSitePlus; Q9CQN3; -.
DR EPD; Q9CQN3; -.
DR jPOST; Q9CQN3; -.
DR MaxQB; Q9CQN3; -.
DR PaxDb; Q9CQN3; -.
DR PeptideAtlas; Q9CQN3; -.
DR PRIDE; Q9CQN3; -.
DR ProteomicsDB; 259153; -.
DR TopDownProteomics; Q9CQN3; -.
DR Antibodypedia; 1581; 79 antibodies from 19 providers.
DR Ensembl; ENSMUST00000113301; ENSMUSP00000108926; ENSMUSG00000033475.
DR Ensembl; ENSMUST00000113302; ENSMUSP00000108927; ENSMUSG00000033475.
DR GeneID; 66119; -.
DR KEGG; mmu:66119; -.
DR UCSC; uc008cvx.2; mouse.
DR CTD; 100188893; -.
DR MGI; MGI:1913369; Tomm6.
DR VEuPathDB; HostDB:ENSMUSG00000033475; -.
DR eggNOG; ENOG502S9AX; Eukaryota.
DR GeneTree; ENSGT00390000002376; -.
DR HOGENOM; CLU_2687147_0_0_1; -.
DR InParanoid; Q9CQN3; -.
DR OMA; VMEWISS; -.
DR OrthoDB; 1571629at2759; -.
DR TreeFam; TF330716; -.
DR Reactome; R-MMU-5205685; PINK1-PRKN Mediated Mitophagy.
DR BioGRID-ORCS; 66119; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Tomm6; mouse.
DR PRO; PR:Q9CQN3; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CQN3; protein.
DR Bgee; ENSMUSG00000033475; Expressed in yolk sac and 92 other tissues.
DR Genevisible; Q9CQN3; MM.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR029182; TOMM6.
DR PANTHER; PTHR15527; PTHR15527; 1.
DR Pfam; PF15184; TOM6p; 1.
PE 3: Inferred from homology;
KW Acetylation; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Protein transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96B49"
FT CHAIN 2..74
FT /note="Mitochondrial import receptor subunit TOM6 homolog"
FT /id="PRO_0000302857"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96B49"
SQ SEQUENCE 74 AA; 7865 MW; 70D5EEF02B17A0FD CRC64;
MASSGVTVSA AGSASEASEV PDNVGDWLRG VFRFATDRND FRRNLILNLG LFAAGVWLAR
NLSDIDLMAP QPGV
