TOM70_NEUCR
ID TOM70_NEUCR Reviewed; 624 AA.
AC P23231; Q9HEG7; Q9UWF1;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Mitochondrial import receptor subunit tom70;
DE AltName: Full=72 kDa mitochondrial outer membrane protein;
DE AltName: Full=Mitochondrial import receptor for the ADP/ATP carrier;
DE AltName: Full=Mitochondrial precursor proteins import receptor;
DE AltName: Full=Translocase of outer membrane tom70;
GN Name=tom70; Synonyms=mom72; ORFNames=2E4.170, NCU04245;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=2177474; DOI=10.1083/jcb.111.6.2353;
RA Steger H.F., Soellner T., Kiebler M., Dietmeier K.A., Pfaller R.,
RA Truelzsch K.S., Tropschug M., Neupert W., Pfanner N.;
RT "Import of ADP/ATP carrier into mitochondria: two receptors act in
RT parallel.";
RL J. Cell Biol. 111:2353-2363(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCN235;
RX PubMed=10501936; DOI=10.1007/s002940050483;
RA Grad L.I., Descheneau A.T., Neupert W., Lill R., Nargang F.E.;
RT "Inactivation of the Neurospora crassa mitochondrial outer membrane protein
RT TOM70 by repeat-induced point mutation (RIP) causes defects in
RT mitochondrial protein import and morphology.";
RL Curr. Genet. 36:137-146(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Receptor that accelerates the import of all mitochondrial
CC precursor proteins. Seems to act in conjunction with mom19.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 8
CC different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and
CC tom70).
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the Tom70 family. {ECO:0000305}.
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DR EMBL; X53735; CAA37767.1; -; mRNA.
DR EMBL; AF110494; AAD21979.1; -; Genomic_DNA.
DR EMBL; AL451022; CAC18318.1; -; Genomic_DNA.
DR EMBL; CM002240; EAA32000.1; -; Genomic_DNA.
DR PIR; A36682; A36682.
DR RefSeq; XP_961236.1; XM_956143.2.
DR AlphaFoldDB; P23231; -.
DR SMR; P23231; -.
DR STRING; 5141.EFNCRP00000003858; -.
DR PRIDE; P23231; -.
DR EnsemblFungi; EAA32000; EAA32000; NCU04245.
DR GeneID; 3877399; -.
DR KEGG; ncr:NCU04245; -.
DR VEuPathDB; FungiDB:NCU04245; -.
DR HOGENOM; CLU_017516_0_1_1; -.
DR InParanoid; P23231; -.
DR OMA; HEATKDM; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0015450; F:protein-transporting ATPase activity; IEA:InterPro.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR005687; Tom70.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR041617; TPR_MalT.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF13181; TPR_8; 1.
DR Pfam; PF17874; TPR_MalT; 1.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; SSF48452; 1.
DR TIGRFAMs; TIGR00990; 3a0801s09; 1.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Receptor;
KW Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..624
FT /note="Mitochondrial import receptor subunit tom70"
FT /id="PRO_0000106338"
FT TOPO_DOM 1..38
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..624
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 136..169
FT /note="TPR 1"
FT REPEAT 171..202
FT /note="TPR 2"
FT REPEAT 204..236
FT /note="TPR 3"
FT REPEAT 302..336
FT /note="TPR 4"
FT REPEAT 340..373
FT /note="TPR 5"
FT REPEAT 375..407
FT /note="TPR 6"
FT REPEAT 408..441
FT /note="TPR 7"
FT REPEAT 443..475
FT /note="TPR 8"
FT REPEAT 476..509
FT /note="TPR 9"
FT REPEAT 517..550
FT /note="TPR 10"
FT REPEAT 551..584
FT /note="TPR 11"
FT REGION 67..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 84..88
FT /note="Missing (in Ref. 1; CAA37767)"
FT /evidence="ECO:0000305"
FT CONFLICT 220..221
FT /note="SD -> RH (in Ref. 1; CAA37767 and 2; AAD21979)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 624 AA; 69341 MW; CC6CC0BF308D706B CRC64;
MAPTIPPPSV PIPAATPVTV PADSSIWDRV SNWVSEHKAV VYTIAGVSVV ITTAGVVYYL
RKGSEQKESG PKLSKKERRK RKQAEKGEAE KASTSKTEEA APTQPKAAAV ESADELPEID
EESVVRLSED ERKAYAAKLK ELGNKAYGSK DFNKAIDLYS KAIICKPDPV YYSNRAACHN
ALAQWEQVVA DTTAALKLDP HYVKALNRRA NAYDQLSRYS DALLDFTASC IIDGFRNEQS
AQAVERLLKK FAENKAKEIL ETKPPKLPSS TFVGNYLQSF RSKPRPEGLE DSVELSEETG
LGQLQLGLKH LESKTGTGYE EGSAAFKKAL DLGELGPHEA LAYNLRGTFH CLMGKHEEAL
ADLSKSIELD PAMTQSYIKR ASMNLELGHP DKAEEDFNKA IEQNAEDPDI YYHRAQLHFI
KGEFAEAAKD YQKSIDLDSD FIFSHIQLGV TQYKMGSIAS SMATFRRCMK NFDQTPDVYN
YYGELLLDQN KFQEAIEKFD TAIALEKETK PMCMNVLPLI NKALALFQWK QDYAEAEQLC
EKALIIDPEC DIAVATMAQL LLQQGKVVEA LKFFERAAEL ARTEGELVNA LSYAEATRTQ
IQVQENYPEL ASKLQGMSGG PGMR
