TOM72_ARATH
ID TOM72_ARATH Reviewed; 77 AA.
AC Q3ECI7;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Mitochondrial import receptor subunit TOM7-2;
DE AltName: Full=Translocase of outer membrane 7 kDa subunit 2;
GN Name=TOM7-2; OrderedLocusNames=At1g64220; ORFNames=F22C12.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=14730085; DOI=10.1104/pp.103.033910;
RA Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L.,
RA Millar A.H., Whelan J.;
RT "A transcriptomic and proteomic characterization of the Arabidopsis
RT mitochondrial protein import apparatus and its response to mitochondrial
RT dysfunction.";
RL Plant Physiol. 134:777-789(2004).
CC -!- FUNCTION: Seems to act as a modulator of the dynamics of the
CC mitochondrial protein transport machinery. Seems to promote the
CC dissociation of subunits of the outer membrane translocase (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 6
CC different proteins (TOM5, TOM6, TOM7, TOM20, TOM22/TOM9 and TOM40).
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, flowers, young cotyledons and
CC leaves. {ECO:0000269|PubMed:14730085}.
CC -!- INDUCTION: Up-regulated after antimycin A or rotenone treatments.
CC {ECO:0000269|PubMed:14730085}.
CC -!- SIMILARITY: Belongs to the Tom7 family. {ECO:0000305}.
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DR EMBL; AC007764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE34211.1; -; Genomic_DNA.
DR RefSeq; NP_176604.1; NM_105096.2.
DR AlphaFoldDB; Q3ECI7; -.
DR SMR; Q3ECI7; -.
DR STRING; 3702.AT1G64220.1; -.
DR PaxDb; Q3ECI7; -.
DR PRIDE; Q3ECI7; -.
DR ProteomicsDB; 234313; -.
DR EnsemblPlants; AT1G64220.1; AT1G64220.1; AT1G64220.
DR GeneID; 842727; -.
DR Gramene; AT1G64220.1; AT1G64220.1; AT1G64220.
DR KEGG; ath:AT1G64220; -.
DR Araport; AT1G64220; -.
DR TAIR; locus:2024623; AT1G64220.
DR eggNOG; ENOG502S8KG; Eukaryota.
DR HOGENOM; CLU_173610_0_1_1; -.
DR InParanoid; Q3ECI7; -.
DR OMA; DPNTHIF; -.
DR OrthoDB; 1608790at2759; -.
DR PhylomeDB; Q3ECI7; -.
DR PRO; PR:Q3ECI7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q3ECI7; baseline and differential.
DR Genevisible; Q3ECI7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:InterPro.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR InterPro; IPR012621; Tom7.
DR Pfam; PF08038; Tom7; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..77
FT /note="Mitochondrial import receptor subunit TOM7-2"
FT /id="PRO_0000046763"
FT TOPO_DOM 1..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 47..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..77
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9ASY8"
SQ SEQUENCE 77 AA; 8362 MW; FAD981590A9A7195 CRC64;
MAAKSTLKIK GKAKPSKGSS SSSSSSASSK YKVFKDWTNW SLQKAKVATH YGFIPLIIII
GMNSDPKPHL FHLLSPV
