ID   TOM7_BOVIN              Reviewed;          55 AA.
AC   Q2KI08;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Mitochondrial import receptor subunit TOM7 homolog;
DE   AltName: Full=Translocase of outer membrane 7 kDa subunit homolog;
GN   Name=TOMM7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for assembly and stability of the TOM complex (By
CC       similarity). Positive regulator of PRKN translocation to damaged
CC       mitochondria. Acts probably by stabilizing PINK1 on the outer membrane
CC       of depolarized mitochondria (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex) which consists of at least 7
CC       different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC       TOMM70). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tom7 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC112813; AAI12814.1; -; mRNA.
DR   RefSeq; NP_001106777.1; NM_001113306.2.
DR   AlphaFoldDB; Q2KI08; -.
DR   SMR; Q2KI08; -.
DR   Ensembl; ENSBTAT00000070920; ENSBTAP00000059589; ENSBTAG00000051150.
DR   GeneID; 614074; -.
DR   KEGG; bta:614074; -.
DR   CTD; 54543; -.
DR   VEuPathDB; HostDB:ENSBTAG00000051150; -.
DR   eggNOG; KOG4449; Eukaryota.
DR   GeneTree; ENSGT00390000014833; -.
DR   InParanoid; Q2KI08; -.
DR   OMA; MPELTIM; -.
DR   OrthoDB; 1608790at2759; -.
DR   Reactome; R-BTA-5205685; PINK1-PRKN Mediated Mitophagy.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000051150; Expressed in oocyte and 106 other tissues.
DR   ExpressionAtlas; Q2KI08; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR   InterPro; IPR012621; Tom7.
DR   Pfam; PF08038; Tom7; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..55
FT                   /note="Mitochondrial import receptor subunit TOM7 homolog"
FT                   /id="PRO_0000244460"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        21..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..55
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   55 AA;  6218 MW;  720E85095C3BEF11 CRC64;
     MVKLSKEAKQ RLQQLFKGGQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL SLLWG