TOM7_HUMAN
ID TOM7_HUMAN Reviewed; 55 AA.
AC Q9P0U1; O95939;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Mitochondrial import receptor subunit TOM7 homolog;
DE AltName: Full=Translocase of outer membrane 7 kDa subunit homolog;
GN Name=TOMM7; Synonyms=TOM7, TOMM07; ORFNames=AD-014;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain tumor;
RX PubMed=10647823; DOI=10.3109/10425179909033947;
RA Lee J.-S.;
RT "Cloning and characterization of the human novel gene encoding 6.2 kDa
RT protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted
RT human glioma M059J cells.";
RL DNA Seq. 10:195-198(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, IDENTIFICATION IN THE TOM COMPLEX WITH TOMM20; TOMM22
RP AND TOMM40, AND TOPOLOGY.
RX PubMed=12198123; DOI=10.1074/jbc.m205613200;
RA Johnston A.J., Hoogenraad J., Dougan D.A., Truscott K.N., Yano M., Mori M.,
RA Hoogenraad N.J., Ryan M.T.;
RT "Insertion and assembly of human tom7 into the preprotein translocase
RT complex of the outer mitochondrial membrane.";
RL J. Biol. Chem. 277:42197-42204(2002).
RN [5]
RP FUNCTION, AND IDENTIFICATION IN THE TOM COMPLEX.
RX PubMed=18331822; DOI=10.1016/j.bbrc.2008.02.150;
RA Kato H., Mihara K.;
RT "Identification of Tom5 and Tom6 in the preprotein translocase complex of
RT human mitochondrial outer membrane.";
RL Biochem. Biophys. Res. Commun. 369:958-963(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [7]
RP FUNCTION.
RX PubMed=24270810; DOI=10.1038/nature12748;
RA Hasson S.A., Kane L.A., Yamano K., Huang C.H., Sliter D.A., Buehler E.,
RA Wang C., Heman-Ackah S.M., Hessa T., Guha R., Martin S.E., Youle R.J.;
RT "High-content genome-wide RNAi screens identify regulators of parkin
RT upstream of mitophagy.";
RL Nature 504:291-295(2013).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: Required for assembly and stability of the TOM complex.
CC Positive regulator of PRKN translocation to damaged mitochondria. Acts
CC probably by stabilizing PINK1 on the outer membrane of depolarized
CC mitochondria. {ECO:0000269|PubMed:18331822,
CC ECO:0000269|PubMed:24270810}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 7
CC different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC TOMM70). {ECO:0000269|PubMed:12198123, ECO:0000269|PubMed:18331822}.
CC -!- INTERACTION:
CC Q9P0U1; Q9NS69: TOMM22; NbExp=2; IntAct=EBI-1180558, EBI-1047508;
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:12198123}; Single-pass membrane protein
CC {ECO:0000269|PubMed:12198123}.
CC -!- SIMILARITY: Belongs to the Tom7 family. {ECO:0000305}.
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DR EMBL; AJ011007; CAB38060.1; -; mRNA.
DR EMBL; AF150733; AAF67473.1; -; mRNA.
DR EMBL; BC001732; AAH01732.1; -; mRNA.
DR CCDS; CCDS5376.1; -.
DR RefSeq; NP_061932.1; NM_019059.3.
DR PDB; 7CK6; EM; 3.40 A; G/H=1-55.
DR PDB; 7CP9; EM; 3.00 A; E/F=1-55.
DR PDBsum; 7CK6; -.
DR PDBsum; 7CP9; -.
DR AlphaFoldDB; Q9P0U1; -.
DR SMR; Q9P0U1; -.
DR BioGRID; 120030; 25.
DR ComplexPortal; CPX-6121; TOM40 mitochondrial outer membrane translocase complex.
DR CORUM; Q9P0U1; -.
DR IntAct; Q9P0U1; 5.
DR STRING; 9606.ENSP00000351214; -.
DR iPTMnet; Q9P0U1; -.
DR PhosphoSitePlus; Q9P0U1; -.
DR BioMuta; TOMM7; -.
DR DMDM; 12643829; -.
DR EPD; Q9P0U1; -.
DR jPOST; Q9P0U1; -.
DR MassIVE; Q9P0U1; -.
DR MaxQB; Q9P0U1; -.
DR PaxDb; Q9P0U1; -.
DR PeptideAtlas; Q9P0U1; -.
DR PRIDE; Q9P0U1; -.
DR ProteomicsDB; 83597; -.
DR TopDownProteomics; Q9P0U1; -.
DR Antibodypedia; 53355; 20 antibodies from 10 providers.
DR DNASU; 54543; -.
DR Ensembl; ENST00000358435.9; ENSP00000351214.4; ENSG00000196683.12.
DR GeneID; 54543; -.
DR KEGG; hsa:54543; -.
DR MANE-Select; ENST00000358435.9; ENSP00000351214.4; NM_019059.5; NP_061932.1.
DR UCSC; uc003svk.6; human.
DR CTD; 54543; -.
DR DisGeNET; 54543; -.
DR GeneCards; TOMM7; -.
DR HGNC; HGNC:21648; TOMM7.
DR HPA; ENSG00000196683; Low tissue specificity.
DR MIM; 607980; gene.
DR neXtProt; NX_Q9P0U1; -.
DR OpenTargets; ENSG00000196683; -.
DR PharmGKB; PA134864325; -.
DR VEuPathDB; HostDB:ENSG00000196683; -.
DR eggNOG; KOG4449; Eukaryota.
DR GeneTree; ENSGT00390000014833; -.
DR HOGENOM; CLU_173610_2_1_1; -.
DR InParanoid; Q9P0U1; -.
DR OMA; IWRYVLV; -.
DR OrthoDB; 1608790at2759; -.
DR PhylomeDB; Q9P0U1; -.
DR TreeFam; TF106199; -.
DR PathwayCommons; Q9P0U1; -.
DR Reactome; R-HSA-1268020; Mitochondrial protein import.
DR Reactome; R-HSA-5205685; PINK1-PRKN Mediated Mitophagy.
DR SignaLink; Q9P0U1; -.
DR SIGNOR; Q9P0U1; -.
DR BioGRID-ORCS; 54543; 37 hits in 1069 CRISPR screens.
DR ChiTaRS; TOMM7; human.
DR GenomeRNAi; 54543; -.
DR Pharos; Q9P0U1; Tbio.
DR PRO; PR:Q9P0U1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9P0U1; protein.
DR Bgee; ENSG00000196683; Expressed in skeletal muscle tissue of rectus abdominis and 210 other tissues.
DR ExpressionAtlas; Q9P0U1; baseline and differential.
DR Genevisible; Q9P0U1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IDA:BHF-UCL.
DR GO; GO:0005739; C:mitochondrion; IDA:BHF-UCL.
DR GO; GO:0008320; F:protein transmembrane transporter activity; TAS:BHF-UCL.
DR GO; GO:0098779; P:positive regulation of mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
DR GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IC:ComplexPortal.
DR GO; GO:0006626; P:protein targeting to mitochondrion; TAS:BHF-UCL.
DR GO; GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
DR InterPro; IPR012621; Tom7.
DR Pfam; PF08038; Tom7; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..55
FT /note="Mitochondrial import receptor subunit TOM7 homolog"
FT /id="PRO_0000046759"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:12198123"
FT TRANSMEM 21..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..55
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000269|PubMed:12198123"
FT CONFLICT 45
FT /note="P -> S (in Ref. 1; CAB38060)"
FT /evidence="ECO:0000305"
FT HELIX 5..37
FT /evidence="ECO:0007829|PDB:7CP9"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:7CK6"
FT HELIX 49..52
FT /evidence="ECO:0007829|PDB:7CP9"
SQ SEQUENCE 55 AA; 6248 MW; 720E850940262ED1 CRC64;
MVKLSKEAKQ RLQQLFKGSQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL SLLWG
