ID   TOM7_MOUSE              Reviewed;          55 AA.
AC   Q9D173;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Mitochondrial import receptor subunit TOM7 homolog;
DE   AltName: Full=Translocase of outer membrane 7 kDa subunit homolog;
GN   Name=Tomm7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for assembly and stability of the TOM complex (By
CC       similarity). Positive regulator of PRKN translocation to damaged
CC       mitochondria. Acts probably by stabilizing PINK1 on the outer membrane
CC       of depolarized mitochondria (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex) which consists of at least 7
CC       different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC       TOMM70). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tom7 family. {ECO:0000305}.
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DR   EMBL; AK003864; BAB23046.1; -; mRNA.
DR   EMBL; BC055352; AAH55352.1; -; mRNA.
DR   CCDS; CCDS39026.1; -.
DR   RefSeq; NP_079670.1; NM_025394.3.
DR   AlphaFoldDB; Q9D173; -.
DR   SMR; Q9D173; -.
DR   STRING; 10090.ENSMUSP00000030851; -.
DR   iPTMnet; Q9D173; -.
DR   PhosphoSitePlus; Q9D173; -.
DR   jPOST; Q9D173; -.
DR   MaxQB; Q9D173; -.
DR   PaxDb; Q9D173; -.
DR   PeptideAtlas; Q9D173; -.
DR   PRIDE; Q9D173; -.
DR   ProteomicsDB; 258950; -.
DR   TopDownProteomics; Q9D173; -.
DR   Antibodypedia; 53355; 20 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000030851; ENSMUSP00000030851; ENSMUSG00000028998.
DR   GeneID; 66169; -.
DR   KEGG; mmu:66169; -.
DR   UCSC; uc008wqs.2; mouse.
DR   CTD; 54543; -.
DR   MGI; MGI:1913419; Tomm7.
DR   VEuPathDB; HostDB:ENSMUSG00000028998; -.
DR   eggNOG; KOG4449; Eukaryota.
DR   GeneTree; ENSGT00390000014833; -.
DR   HOGENOM; CLU_173610_2_1_1; -.
DR   InParanoid; Q9D173; -.
DR   OMA; MPELTIM; -.
DR   OrthoDB; 1608790at2759; -.
DR   PhylomeDB; Q9D173; -.
DR   TreeFam; TF106199; -.
DR   Reactome; R-MMU-5205685; PINK1-PRKN Mediated Mitophagy.
DR   BioGRID-ORCS; 66169; 15 hits in 68 CRISPR screens.
DR   ChiTaRS; Tomm7; mouse.
DR   PRO; PR:Q9D173; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9D173; protein.
DR   Bgee; ENSMUSG00000028998; Expressed in ileal epithelium and 258 other tissues.
DR   Genevisible; Q9D173; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0098779; P:positive regulation of mitophagy in response to mitochondrial depolarization; ISO:MGI.
DR   GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; ISO:MGI.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR   GO; GO:0031647; P:regulation of protein stability; ISO:MGI.
DR   InterPro; IPR012621; Tom7.
DR   Pfam; PF08038; Tom7; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..55
FT                   /note="Mitochondrial import receptor subunit TOM7 homolog"
FT                   /id="PRO_0000046760"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..55
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   55 AA;  6177 MW;  690E93658C3BEF15 CRC64;
     MVKLSKEAKQ RLQQLFKGGQ FAIRWGFIPL VIYLGFTRGA DPGMPEPSVL SLLWG