ID   TOM7_PIG                Reviewed;          55 AA.
AC   A1XQS2;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Mitochondrial import receptor subunit TOM7 homolog;
DE   AltName: Full=Translocase of outer membrane 7 kDa subunit homolog;
GN   Name=TOMM7;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Longissimus dorsi muscle;
RA   Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.;
RT   "Generation and analysis of cDNA sequences derived from a porcine skeletal
RT   muscle library.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for assembly and stability of the TOM complex (By
CC       similarity). Positive regulator of PRKN translocation to damaged
CC       mitochondria. Acts probably by stabilizing PINK1 on the outer membrane
CC       of depolarized mitochondria (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex) which consists of at least 7
CC       different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and
CC       TOMM70). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tom7 family. {ECO:0000305}.
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DR   EMBL; DQ629143; ABK55628.1; -; mRNA.
DR   RefSeq; NP_001090936.1; NM_001097467.1.
DR   AlphaFoldDB; A1XQS2; -.
DR   SMR; A1XQS2; -.
DR   STRING; 9823.ENSSSCP00000016311; -.
DR   PaxDb; A1XQS2; -.
DR   PeptideAtlas; A1XQS2; -.
DR   Ensembl; ENSSSCT00000016759; ENSSSCP00000016311; ENSSSCG00000015384.
DR   Ensembl; ENSSSCT00005015965; ENSSSCP00005009537; ENSSSCG00005010374.
DR   Ensembl; ENSSSCT00015107881; ENSSSCP00015045662; ENSSSCG00015079497.
DR   Ensembl; ENSSSCT00025076532; ENSSSCP00025033182; ENSSSCG00025055951.
DR   Ensembl; ENSSSCT00030100547; ENSSSCP00030046357; ENSSSCG00030071803.
DR   Ensembl; ENSSSCT00035062164; ENSSSCP00035025091; ENSSSCG00035046741.
DR   Ensembl; ENSSSCT00040022337; ENSSSCP00040009350; ENSSSCG00040016608.
DR   Ensembl; ENSSSCT00045060659; ENSSSCP00045042606; ENSSSCG00045035324.
DR   Ensembl; ENSSSCT00050073808; ENSSSCP00050031796; ENSSSCG00050054138.
DR   Ensembl; ENSSSCT00055029599; ENSSSCP00055023560; ENSSSCG00055015015.
DR   Ensembl; ENSSSCT00060086632; ENSSSCP00060037468; ENSSSCG00060063503.
DR   Ensembl; ENSSSCT00065061675; ENSSSCP00065026730; ENSSSCG00065045071.
DR   Ensembl; ENSSSCT00070012893; ENSSSCP00070010613; ENSSSCG00070006724.
DR   GeneID; 100037982; -.
DR   KEGG; ssc:100037982; -.
DR   CTD; 54543; -.
DR   VGNC; VGNC:107175; TOMM7.
DR   eggNOG; KOG4449; Eukaryota.
DR   GeneTree; ENSGT00390000014833; -.
DR   HOGENOM; CLU_173610_2_1_1; -.
DR   InParanoid; A1XQS2; -.
DR   OMA; MPELTIM; -.
DR   OrthoDB; 1608790at2759; -.
DR   TreeFam; TF106199; -.
DR   Reactome; R-SSC-5205685; PINK1-PRKN Mediated Mitophagy.
DR   Proteomes; UP000008227; Chromosome 9.
DR   Proteomes; UP000314985; Chromosome 9.
DR   Bgee; ENSSSCG00000015384; Expressed in longissimus lumborum muscle and 44 other tissues.
DR   Genevisible; A1XQS2; SS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0098779; P:positive regulation of mitophagy in response to mitochondrial depolarization; IEA:Ensembl.
DR   GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR   GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR   InterPro; IPR012621; Tom7.
DR   Pfam; PF08038; Tom7; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..55
FT                   /note="Mitochondrial import receptor subunit TOM7 homolog"
FT                   /id="PRO_0000289989"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        21..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..55
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   55 AA;  6218 MW;  720E85095C3BEF11 CRC64;
     MVKLSKEAKQ RLQQLFKGGQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL SLLWG