TOM92_ARATH
ID TOM92_ARATH Reviewed; 99 AA.
AC Q9FNC9;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Mitochondrial import receptor subunit TOM9-2;
DE AltName: Full=Mitochondrial import receptor subunit TOM22 homolog 2;
DE AltName: Full=Translocase of outer membrane 22 kDa subunit homolog 2;
DE AltName: Full=Translocase of outer membrane 9 kDa subunit TOM9-2;
GN Name=TOM9-2; Synonyms=TOM22-2; OrderedLocusNames=At5g43970;
GN ORFNames=MRH10.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAB09057.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAK97740.1}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAK97740.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAK97740.1}
RP PROTEIN SEQUENCE OF 2-99.
RA Werhahn W., Braun H.-P.;
RT "Characterization of the TOM22 subunit of preprotein translocase of the
RT outer mitochondrial membrane from Arabidopsis thaliana.";
RL Submitted (AUG-2001) to UniProtKB.
RN [6]
RP PROTEIN SEQUENCE OF 2-6; 22-32 AND 74-94, SUBUNIT, AND SUBCELLULAR
RP LOCATION.
RA Werhahn W., Jaensch L., Braun H.-P.;
RT "Identification of novel subunits of the TOM complex from Arabidopsis
RT thaliana.";
RL Plant Physiol. Biochem. 41:407-416(2003).
RN [7]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=14730085; DOI=10.1104/pp.103.033910;
RA Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L.,
RA Millar A.H., Whelan J.;
RT "A transcriptomic and proteomic characterization of the Arabidopsis
RT mitochondrial protein import apparatus and its response to mitochondrial
RT dysfunction.";
RL Plant Physiol. 134:777-789(2004).
CC -!- FUNCTION: Central component of the receptor complex responsible for the
CC recognition and translocation of cytosolically synthesized
CC mitochondrial preproteins. Together with TOM20 functions as the transit
CC peptide receptor at the surface of the mitochondrion outer membrane and
CC facilitates the movement of preproteins into the translocation pore (By
CC similarity). {ECO:0000250|UniProtKB:P49334}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex) which consists of at least 6
CC different proteins (TOM5, TOM6, TOM7, TOM20, TOM22/TOM9 and TOM40).
CC {ECO:0000269|Ref.6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:14730085, ECO:0000269|Ref.6}; Single-pass type II
CC membrane protein {ECO:0000269|PubMed:14730085, ECO:0000269|Ref.6}.
CC -!- TISSUE SPECIFICITY: Expressed in young cotyledons, roots, flowers and
CC leaves. {ECO:0000269|PubMed:14730085}.
CC -!- SIMILARITY: Belongs to the Tom22 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB006703; BAB09057.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95039.1; -; Genomic_DNA.
DR EMBL; AY052270; AAK97740.1; -; mRNA.
DR EMBL; AY060520; AAL31133.1; -; mRNA.
DR EMBL; AY088551; AAM66083.1; -; mRNA.
DR RefSeq; NP_199210.1; NM_123764.3.
DR AlphaFoldDB; Q9FNC9; -.
DR SMR; Q9FNC9; -.
DR BioGRID; 19670; 2.
DR IntAct; Q9FNC9; 3.
DR STRING; 3702.AT5G43970.1; -.
DR PaxDb; Q9FNC9; -.
DR PRIDE; Q9FNC9; -.
DR ProteomicsDB; 234376; -.
DR EnsemblPlants; AT5G43970.1; AT5G43970.1; AT5G43970.
DR GeneID; 834420; -.
DR Gramene; AT5G43970.1; AT5G43970.1; AT5G43970.
DR KEGG; ath:AT5G43970; -.
DR Araport; AT5G43970; -.
DR TAIR; locus:2172482; AT5G43970.
DR eggNOG; KOG4111; Eukaryota.
DR HOGENOM; CLU_172840_0_0_1; -.
DR InParanoid; Q9FNC9; -.
DR OMA; MNELEMQ; -.
DR OrthoDB; 1577431at2759; -.
DR PhylomeDB; Q9FNC9; -.
DR PRO; PR:Q9FNC9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FNC9; baseline and differential.
DR Genevisible; Q9FNC9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; ISS:TAIR.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0015450; F:protein-transporting ATPase activity; ISS:TAIR.
DR GO; GO:0006626; P:protein targeting to mitochondrion; ISS:TAIR.
DR InterPro; IPR005683; Tom22.
DR InterPro; IPR017411; Tom22_pln.
DR PANTHER; PTHR46867; PTHR46867; 1.
DR Pfam; PF04281; Tom22; 1.
DR PIRSF; PIRSF038151; TOM9-2_plant; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Protein transport; Receptor;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.5, ECO:0000269|Ref.6"
FT CHAIN 2..99
FT /note="Mitochondrial import receptor subunit TOM9-2"
FT /id="PRO_0000076110"
FT TOPO_DOM 2..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..99
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
SQ SEQUENCE 99 AA; 10378 MW; 0D468E9A9153D263 CRC64;
MAAKRIGAGK SGGGDPNILA RISNSEIVSQ GRRAAGDAVE VSKKLLRSTG KAAWIAGTTF
LILVVPLIIE MDREAQINEI ELQQASLLGA PPSPMQRGL
