ID   TOMB_ECOL6              Reviewed;         124 AA.
AC   P0AAR1; P37611; P75708;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Hha toxicity modulator TomB;
GN   Name=tomB; OrderedLocusNames=c0579;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=23055930; DOI=10.1371/journal.ppat.1002954;
RA   Norton J.P., Mulvey M.A.;
RT   "Toxin-antitoxin systems are important for niche-specific colonization and
RT   stress resistance of uropathogenic Escherichia coli.";
RL   PLoS Pathog. 8:E1002954-E1002954(2012).
CC   -!- FUNCTION: Attenuates Hha toxicity and regulates biofilm formation.
CC       Binds to various coding and intergenic regions of genomic DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the tomB-hha operon causes reduced
CC       infection of the mouse bladder but not of the kidney.
CC       {ECO:0000269|PubMed:23055930}.
CC   -!- SIMILARITY: Belongs to the TomB family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN79057.1; -; Genomic_DNA.
DR   RefSeq; WP_000344800.1; NC_004431.1.
DR   AlphaFoldDB; P0AAR1; -.
DR   SMR; P0AAR1; -.
DR   STRING; 199310.c0579; -.
DR   EnsemblBacteria; AAN79057; AAN79057; c0579.
DR   GeneID; 66671237; -.
DR   KEGG; ecc:c0579; -.
DR   eggNOG; ENOG502ZC6G; Bacteria.
DR   HOGENOM; CLU_164850_0_0_6; -.
DR   OMA; CERVEKY; -.
DR   BioCyc; ECOL199310:C0579-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR019693; Biofilm_formation_reg_YbaJ.
DR   Pfam; PF10757; YbaJ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding.
FT   CHAIN           1..124
FT                   /note="Hha toxicity modulator TomB"
FT                   /id="PRO_0000168619"
SQ   SEQUENCE   124 AA;  14557 MW;  5F410DFFBD29F270 CRC64;
     MDEYSPKRHD IAQLKFLCET LYHDCLANLE ESNHGWVNDP TSAINLQLNE LIEHIATFAL
     NYKIKYNEDN KLIEQIDEYL DDTFMLFSSY GINMQDLQKW RKSGNRLFRC FVNATKENPA
     SLSC