TON1A_ARATH
ID TON1A_ARATH Reviewed; 260 AA.
AC Q9FQ25;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Protein TONNEAU 1a;
DE AltName: Full=Protein TONNEAU 1;
GN Name=TON1A; Synonyms=TON1; OrderedLocusNames=At3g55000; ORFNames=F28P10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH CEN1,
RP SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=18757558; DOI=10.1105/tpc.107.056812;
RA Azimzadeh J., Nacry P., Christodoulidou A., Drevensek S., Camilleri C.,
RA Amiour N., Parcy F., Pastuglia M., Bouchez D.;
RT "Arabidopsis TONNEAU1 proteins are essential for preprophase band formation
RT and interact with centrin.";
RL Plant Cell 20:2146-2159(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH LNG1 AND LNG2, AND SUBCELLULAR LOCATION.
RX PubMed=22286137; DOI=10.1105/tpc.111.089748;
RA Drevensek S., Goussot M., Duroc Y., Christodoulidou A., Steyaert S.,
RA Schaefer E., Duvernois E., Grandjean O., Vantard M., Bouchez D.,
RA Pastuglia M.;
RT "The Arabidopsis TRM1-TON1 interaction reveals a recruitment network common
RT to plant cortical microtubule arrays and eukaryotic centrosomes.";
RL Plant Cell 24:178-191(2012).
CC -!- FUNCTION: Involved in the control of the dynamic organization of the
CC cortical cytoskeleton. May play a role in the organization of
CC microtubule arrays at the centrosome through interaction with centrin 1
CC (CEN1). {ECO:0000269|PubMed:18757558}.
CC -!- SUBUNIT: Interacts with CEN1, LNG1/TRM2 and LNG2/TRM1 (via C-terminus).
CC {ECO:0000269|PubMed:18757558, ECO:0000269|PubMed:22286137}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18757558,
CC ECO:0000269|PubMed:22286137}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:18757558, ECO:0000269|PubMed:22286137}.
CC Note=Localizes to cytoplasm and cortical cytoskeletal structures,
CC including the preprophase band and the interphase microtubule arrays
CC (PubMed:18757558). Recruited to cytoskeletal structures by LNG2/TRM1
CC (PubMed:22286137). {ECO:0000269|PubMed:18757558,
CC ECO:0000269|PubMed:22286137}.
CC -!- DISRUPTION PHENOTYPE: Extreme defects in morphogenesis, positioning of
CC mitotic division planes and cellular organization due to dysfunction of
CC the cortical cytoskeleton and absence of the preprophase band of
CC microtubules. In the ton1 insertional mutant, the two highly similar
CC genes in tandem, TON1A and TON1B are simultaneously disrupted.
CC {ECO:0000269|PubMed:18757558}.
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DR EMBL; AF280058; AAG35779.1; -; Genomic_DNA.
DR EMBL; AL049655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002686; AEE79325.1; -; Genomic_DNA.
DR EMBL; AK117295; BAC41967.1; -; mRNA.
DR EMBL; BT024487; ABD19668.1; -; mRNA.
DR RefSeq; NP_567012.1; NM_115357.4.
DR AlphaFoldDB; Q9FQ25; -.
DR SMR; Q9FQ25; -.
DR BioGRID; 9981; 5.
DR IntAct; Q9FQ25; 1.
DR STRING; 3702.AT3G55000.1; -.
DR iPTMnet; Q9FQ25; -.
DR PaxDb; Q9FQ25; -.
DR PRIDE; Q9FQ25; -.
DR ProteomicsDB; 234312; -.
DR EnsemblPlants; AT3G55000.1; AT3G55000.1; AT3G55000.
DR GeneID; 824665; -.
DR Gramene; AT3G55000.1; AT3G55000.1; AT3G55000.
DR KEGG; ath:AT3G55000; -.
DR Araport; AT3G55000; -.
DR TAIR; locus:2082662; AT3G55000.
DR eggNOG; ENOG502QRFJ; Eukaryota.
DR HOGENOM; CLU_071412_0_0_1; -.
DR InParanoid; Q9FQ25; -.
DR OMA; KDEFNWR; -.
DR OrthoDB; 1163584at2759; -.
DR PhylomeDB; Q9FQ25; -.
DR PRO; PR:Q9FQ25; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9FQ25; baseline and differential.
DR Genevisible; Q9FQ25; AT.
DR GO; GO:0005938; C:cell cortex; IDA:TAIR.
DR GO; GO:0030863; C:cortical cytoskeleton; IDA:TAIR.
DR GO; GO:0030981; C:cortical microtubule cytoskeleton; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0009574; C:preprophase band; IDA:TAIR.
DR GO; GO:0030865; P:cortical cytoskeleton organization; IMP:UniProtKB.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:UniProtKB.
DR GO; GO:0000913; P:preprophase band assembly; IMP:UniProtKB.
DR InterPro; IPR006594; LisH.
DR Pfam; PF16045; LisH_2; 1.
DR PROSITE; PS50896; LISH; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..260
FT /note="Protein TONNEAU 1a"
FT /id="PRO_0000420916"
FT DOMAIN 73..105
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT REGION 147..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 29334 MW; AECBE26FDEE6540D CRC64;
MDDYTREMMD LKTLVTRTLE KKGVLAKIRA ELRASVFEAI EEEDRVIENN EGPPPALLGS
CNDRARKLHA SPSGRLLSAL ICEYLDWAQL NHTLIVYQPE SNLPKDSWKS ELRDFNSNNG
FELNRNGDSG PLLLDVLEGF LKFESMTQGM GSSSRRDSET ESSSSLESRN PPRRSSASDS
LPPQRRPVSA SQASDRRAGL STSGYRKDEF NWRQGNQDTH EEVTRASAAL ENLQLDRKTR
NLTSSWRNVR DGTNEEEGRD
