ID   TONB_HAEDU              Reviewed;         279 AA.
AC   O51810;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Protein TonB;
GN   Name=tonB; OrderedLocusNames=HD_0327;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RX   PubMed=9423852; DOI=10.1128/iai.66.1.151-160.1998;
RA   Elkins C., Totten P.A., Olsen B., Thomas C.E.;
RT   "Role of the Haemophilus ducreyi Ton system in internalization of heme from
RT   hemoglobin.";
RL   Infect. Immun. 66:151-160(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC       out high-affinity binding and energy dependent uptake into the
CC       periplasmic space of specific substrates. It could act to transduce
CC       energy from the cytoplasmic membrane to specific energy-requiring
CC       processes in the outer membrane, resulting in the release into the
CC       periplasm of ligands bound by these outer membrane proteins. Required
CC       for heme utilization and virulence (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
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DR   EMBL; AF001034; AAC01947.1; -; Genomic_DNA.
DR   EMBL; AE017143; AAP95304.1; -; Genomic_DNA.
DR   RefSeq; WP_010944357.1; NC_002940.2.
DR   AlphaFoldDB; O51810; -.
DR   SMR; O51810; -.
DR   STRING; 233412.HD_0327; -.
DR   EnsemblBacteria; AAP95304; AAP95304; HD_0327.
DR   KEGG; hdu:HD_0327; -.
DR   eggNOG; COG0810; Bacteria.
DR   HOGENOM; CLU_917659_0_0_6; -.
DR   OMA; SEAQAYN; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031992; F:energy transducer activity; IEA:InterPro.
DR   GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003538; TonB.
DR   InterPro; IPR006260; TonB/TolA_C.
DR   InterPro; IPR037682; TonB_C.
DR   Pfam; PF03544; TonB_C; 1.
DR   PRINTS; PR01374; TONBPROTEIN.
DR   TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..279
FT                   /note="Protein TonB"
FT                   /id="PRO_0000196196"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..27
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..279
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          57..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..80
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   279 AA;  29607 MW;  2F7A3EDD4D60B1EE CRC64;
     MKQKHSRIGL ISSVFIHIVL FASFISLVEV SHSDLSDGDS PLSIELVAAL LEQPQVAVAP
     EEVTSTEPET FDEEPEPEPD AIPEPITKPI EKPKEKPKEK PKKPEKPKEK LKKEKPKEKA
     KQIEALEKGP EAKQGIVAQA VPGALQGKKE QVGISNGNPN GNSASSSDTG LVNGVLGGNG
     NGASSNEINA YKAALQRALQ HRANNAYPAR EKMMRKTGVV TLGFTISPSG KLIDVTVLNS
     SGNQNLDAAA VQAAEATKVA PPPIGFPPNV TVPIKFSIQ