TONB_HAEIN
ID TONB_HAEIN Reviewed; 270 AA.
AC P42872;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein TonB;
GN Name=tonB; OrderedLocusNames=HI_0251;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NTHi TN106;
RX PubMed=8188372; DOI=10.1128/iai.62.6.2470-2477.1994;
RA Jarosik G.P., Sanders J.D., Cope L.D., Mueller-Eberhard U., Hansen E.J.;
RT "A functional tonB gene is required for both utilization of heme and
RT virulence expression by Haemophilus influenzae type b.";
RL Infect. Immun. 62:2470-2477(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC out high-affinity binding and energy dependent uptake into the
CC periplasmic space of specific substrates. It could act to transduce
CC energy from the cytoplasmic membrane to specific energy-requiring
CC processes in the outer membrane, resulting in the release into the
CC periplasm of ligands bound by these outer membrane proteins. Required
CC for heme utilization and virulence.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
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DR EMBL; U04996; AAA60460.1; -; Genomic_DNA.
DR EMBL; L42023; AAC21917.1; -; Genomic_DNA.
DR PIR; F64057; F64057.
DR RefSeq; NP_438420.1; NC_000907.1.
DR RefSeq; WP_010868966.1; NC_000907.1.
DR AlphaFoldDB; P42872; -.
DR SMR; P42872; -.
DR STRING; 71421.HI_0251; -.
DR EnsemblBacteria; AAC21917; AAC21917; HI_0251.
DR KEGG; hin:HI_0251; -.
DR PATRIC; fig|71421.8.peg.266; -.
DR eggNOG; COG0810; Bacteria.
DR HOGENOM; CLU_076333_5_0_6; -.
DR OMA; SEAQAYN; -.
DR BioCyc; HINF71421:G1GJ1-265-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0031992; F:energy transducer activity; IBA:GO_Central.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003538; TonB.
DR InterPro; IPR006260; TonB/TolA_C.
DR InterPro; IPR037682; TonB_C.
DR Pfam; PF03544; TonB_C; 1.
DR PRINTS; PR01374; TONBPROTEIN.
DR TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW Transmembrane helix; Transport; Virulence.
FT CHAIN 1..270
FT /note="Protein TonB"
FT /id="PRO_0000196197"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..27
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..270
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 70..71
FT /note="1"
FT REPEAT 72..73
FT /note="2"
FT REPEAT 74..75
FT /note="3"
FT REPEAT 76..77
FT /note="4"
FT REGION 56..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..77
FT /note="4 X 2 AA tandem repeats of E-P"
FT COMPBIAS 62..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..130
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 17
FT /note="A -> V (in strain: TN106)"
FT VARIANT 31
FT /note="E -> K (in strain: TN106)"
FT VARIANT 66
FT /note="D -> N (in strain: TN106)"
FT VARIANT 76..84
FT /note="Missing (in strain: TN106)"
FT VARIANT 116
FT /note="G -> E (in strain: TN106)"
FT VARIANT 120
FT /note="G -> E (in strain: TN106)"
FT VARIANT 134
FT /note="K -> Q (in strain: TN106)"
FT VARIANT 140
FT /note="E -> D (in strain: TN106)"
FT VARIANT 146
FT /note="E -> K (in strain: TN106)"
FT VARIANT 226
FT /note="K -> R (in strain: TN106)"
SQ SEQUENCE 270 AA; 29193 MW; 4CDA54B46F7D10A0 CRC64;
MQQTKRSLLG LLISLIAHGI VIGFILWNWN EPSDSANSAQ GDISTSISME LLQGMVLEEP
APEPEDVQKE PEPEPEPGNV QKEPEPEKQE IVEDPTIKPE PKKIKEPEKE KPKPKGKPKG
KPKNKPKKEV KPQKKPINKE LPKGDENIDS SANVNDKAST TSAANSNAQV AGSGTDTSEI
AAYRSAIRRE IESHKRYPTR AKIMRKQGKV SVSFNVGADG SLSGAKVTKS SGDESLDKAA
LDAINVSRSV GTRPAGFPSS LSVQISFTLQ
