TONB_HELPJ
ID TONB_HELPJ Reviewed; 280 AA.
AC Q9ZJP4;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Protein TonB;
GN Name=tonB; OrderedLocusNames=jhp_1260;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC out high-affinity binding and energy dependent uptake into the
CC periplasmic space of specific substrates. It could act to transduce
CC energy from the cytoplasmic membrane to specific energy-requiring
CC processes in the outer membrane, resulting in the release into the
CC periplasm of ligands bound by these outer membrane proteins (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
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DR EMBL; AE001439; AAD06833.1; -; Genomic_DNA.
DR PIR; F71829; F71829.
DR RefSeq; WP_000703806.1; NZ_CP011330.1.
DR AlphaFoldDB; Q9ZJP4; -.
DR SMR; Q9ZJP4; -.
DR STRING; 85963.jhp_1260; -.
DR EnsemblBacteria; AAD06833; AAD06833; jhp_1260.
DR KEGG; hpj:jhp_1260; -.
DR PATRIC; fig|85963.30.peg.1311; -.
DR eggNOG; COG0810; Bacteria.
DR OMA; SEAQAYN; -.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031992; F:energy transducer activity; IEA:InterPro.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003538; TonB.
DR InterPro; IPR006260; TonB/TolA_C.
DR InterPro; IPR037682; TonB_C.
DR Pfam; PF03544; TonB_C; 1.
DR PRINTS; PR01374; TONBPROTEIN.
DR TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport; Repeat;
KW Signal-anchor; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..280
FT /note="Protein TonB"
FT /id="PRO_0000196199"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..280
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REGION 56..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 31046 MW; 640717A8BF81D76D CRC64;
MKISPSPRKL SKVSTSVSFL ISFALYAIGF GYFLLREDAP EPLAQAGTTK VTMSLASINT
NSNTKTNAES AKPKEEPKEK PKKEEPKKEE PKKETKPKPK PKPKPKPKPK PKPKPEPKPK
PEPKVEEPKK EEPKEEPKKE EAKEEAKEKS VPKQVTTKDI VKEKDKQEES NKTSEGATSE
AQAYNPGVSN EFLMKIQTAI SSKNRYPKMA QIRGIEGEVL VSFTINADGS VTDIKVVKSN
TTDILNHAAL EAIKSAAHLF PKPDETVHLK IPIAYSLKED
