TONB_HELPY
ID TONB_HELPY Reviewed; 285 AA.
AC O25899;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Protein TonB;
GN Name=tonB; OrderedLocusNames=HP_1341;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC out high-affinity binding and energy dependent uptake into the
CC periplasmic space of specific substrates. It could act to transduce
CC energy from the cytoplasmic membrane to specific energy-requiring
CC processes in the outer membrane, resulting in the release into the
CC periplasm of ligands bound by these outer membrane proteins (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08383.1; -; Genomic_DNA.
DR PIR; E64687; E64687.
DR RefSeq; NP_208133.1; NC_000915.1.
DR RefSeq; WP_000703807.1; NC_018939.1.
DR PDB; 5LW8; NMR; -; A=194-285.
DR PDB; 6SLY; NMR; -; A=179-285.
DR PDBsum; 5LW8; -.
DR PDBsum; 6SLY; -.
DR AlphaFoldDB; O25899; -.
DR BMRB; O25899; -.
DR SMR; O25899; -.
DR IntAct; O25899; 1.
DR MINT; O25899; -.
DR STRING; 85962.C694_06920; -.
DR PaxDb; O25899; -.
DR EnsemblBacteria; AAD08383; AAD08383; HP_1341.
DR KEGG; hpy:HP_1341; -.
DR PATRIC; fig|85962.47.peg.1436; -.
DR eggNOG; COG0810; Bacteria.
DR OMA; SEAQAYN; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0031992; F:energy transducer activity; IBA:GO_Central.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003538; TonB.
DR InterPro; IPR006260; TonB/TolA_C.
DR InterPro; IPR037682; TonB_C.
DR Pfam; PF03544; TonB_C; 1.
DR PRINTS; PR01374; TONBPROTEIN.
DR TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW Protein transport; Reference proteome; Repeat; Signal-anchor;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..285
FT /note="Protein TonB"
FT /id="PRO_0000196198"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..285
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REGION 55..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 185..189
FT /evidence="ECO:0007829|PDB:6SLY"
FT HELIX 197..208
FT /evidence="ECO:0007829|PDB:5LW8"
FT HELIX 215..218
FT /evidence="ECO:0007829|PDB:5LW8"
FT STRAND 222..230
FT /evidence="ECO:0007829|PDB:5LW8"
FT TURN 232..234
FT /evidence="ECO:0007829|PDB:6SLY"
FT STRAND 236..246
FT /evidence="ECO:0007829|PDB:5LW8"
FT HELIX 248..260
FT /evidence="ECO:0007829|PDB:5LW8"
FT HELIX 262..264
FT /evidence="ECO:0007829|PDB:5LW8"
FT STRAND 274..280
FT /evidence="ECO:0007829|PDB:5LW8"
SQ SEQUENCE 285 AA; 31585 MW; 3897A8BB7B70BDF8 CRC64;
MKISPSPRKL SKVSTSVSFL ISFALYAIGF GYFLLREDAP EPLAQAGTTK VTMSLASINT
NSNTKTNAES AKPKEEPKEK PKKEEPKKEE PKKEVTKPKP KPKPKPKPKP KPKPEPKPEP
KPEPKPEPKV EEVKKEEPKE EPKKEEAKEE AKEKSAPKQV TTKDIVKEKD KQEESNKTSE
GATSEAQAYN PGVSNEFLMK IQTAISSKNR YPKMAQIRGI EGEVLVSFTI NADGSVTDIK
VVKSNTTDIL NHAALEAIKS AAHLFPKPEE TVHLKIPIAY SLKED
