TONB_KLEAK
ID TONB_KLEAK Reviewed; 243 AA.
AC P46383; G0E3D2;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein TonB;
GN Name=tonB; OrderedLocusNames=EAE_16950;
OS Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235
OS / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)
OS (Enterobacter aerogenes).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1028307;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS.
RC STRAIN=ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC
RC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56;
RX PubMed=8407788; DOI=10.1128/jb.175.19.6158-6168.1993;
RA Bruske A.K., Heller K.J.;
RT "Molecular characterization of the Enterobacter aerogenes tonB gene:
RT identification of a novel type of tonB box suppressor mutant.";
RL J. Bacteriol. 175:6158-6168(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC
RC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56;
RX PubMed=22493190; DOI=10.1128/jb.00028-12;
RA Shin S.H., Kim S., Kim J.Y., Lee S., Um Y., Oh M.K., Kim Y.R., Lee J.,
RA Yang K.S.;
RT "Complete genome sequence of Enterobacter aerogenes KCTC 2190.";
RL J. Bacteriol. 194:2373-2374(2012).
CC -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC out high-affinity binding and energy dependent uptake into the
CC periplasmic space of specific substrates. It could act to transduce
CC energy from the cytoplasmic membrane to specific energy-requiring
CC processes in the outer membrane, resulting in the release into the
CC periplasm of ligands bound by these outer membrane proteins.
CC -!- SUBUNIT: Homodimer. Forms a complex with the accessory proteins ExbB
CC and ExbD (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEG98301.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X68477; CAA48496.1; -; Genomic_DNA.
DR EMBL; CP002824; AEG98301.1; ALT_INIT; Genomic_DNA.
DR PIR; A36928; A36928.
DR RefSeq; YP_004593580.1; NC_015663.1.
DR AlphaFoldDB; P46383; -.
DR SMR; P46383; -.
DR STRING; 1028307.EAE_16950; -.
DR EnsemblBacteria; AEG98301; AEG98301; EAE_16950.
DR KEGG; eae:EAE_16950; -.
DR PATRIC; fig|1028307.3.peg.3390; -.
DR eggNOG; COG0810; Bacteria.
DR HOGENOM; CLU_098618_0_0_6; -.
DR Proteomes; UP000008881; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031992; F:energy transducer activity; IEA:InterPro.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003538; TonB.
DR InterPro; IPR006260; TonB/TolA_C.
DR InterPro; IPR037682; TonB_C.
DR Pfam; PF03544; TonB_C; 1.
DR PRINTS; PR01374; TONBPROTEIN.
DR TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport; Repeat;
KW Signal-anchor; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..243
FT /note="Protein TonB"
FT /id="PRO_0000196195"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..29
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..243
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 70..71
FT /note="1-1"
FT REPEAT 72..73
FT /note="1-2"
FT REPEAT 74..75
FT /note="1-3"
FT REPEAT 76..77
FT /note="1-4"
FT REPEAT 97..98
FT /note="2-1"
FT REPEAT 99..100
FT /note="2-2"
FT REPEAT 101..102
FT /note="2-3"
FT REPEAT 103..104
FT /note="2-4"
FT REPEAT 105..106
FT /note="2-5"
FT REPEAT 107..108
FT /note="2-6"
FT REGION 58..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..77
FT /note="4 X 2 AA tandem repeats of E-P"
FT REGION 97..108
FT /note="6 X 2 AA tandem repeats of K-P"
FT COMPBIAS 106..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 157
FT /note="G -> V (in Ref. 1; CAA48496)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 243 AA; 26679 MW; 3DC275AE6284E1DD CRC64;
MTLDLPRRFP WPTLLSVAIH GAVVAGLLYT SVHQVIEKPS PSQPIEITMV APADLEPPQA
AQPVVEPVVE PEPEPEPEVV PEPPKEVPVV IHKPEPKPKP KPKPKPKPEK KVEPKREVKP
AEPRPVSPFE NNNTAPARTA PSTTAATAKP MTTAPSGPKA LKRGDPSYPQ RAQALRIEGD
VRVKFDVTAD GRVENIQILS AKPANMFERD VKTAMRKWRY EAGRPGTGLT MNIKFRLNGV
KMD
